Leonardo Tozzi
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Explore the profile of Leonardo Tozzi including associated specialties, affiliations and a list of published articles.
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1603
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Recent Articles
1.
Williams L, Hack L, Jubeir J, Hilton R, Tozzi L, Boyar L, et al.
Res Sq
. 2025 Mar;
PMID: 40060043
Cognitive impairments contribute significantly to psychosocial dysfunction in major depressive disorder (MDD), yet mechanistically selective treatments targeted to these impairments are lacking. We evaluated guanfacine immediate release (GIR), an alpha...
2.
Tozzi L, Bertrand C, Hack L, Lyons T, Olmsted A, Rajasekharan D, et al.
Nat Ment Health
. 2025 Feb;
2(8):987-998.
PMID: 39911692
We previously identified a cognitive biotype of depression characterized by treatment resistance, impaired cognitive control behavioral performance and dysfunction in the cognitive control circuit, comprising the dorsolateral prefrontal cortex (dLPFC)...
3.
Akiki T, Jubeir J, Bertrand C, Tozzi L, Williams L
Nat Rev Neurosci
. 2024 Nov;
26(1):5-22.
PMID: 39604513
Anxiety disorders are the most prevalent mental health conditions worldwide. Unfortunately, the understanding of the precise neurobiological mechanisms that underlie these disorders remains limited. Current diagnostic classifications, based on observable...
4.
Zhang X, Pines A, Stetz P, Goldstein-Piekarski A, Xiao L, Lv N, et al.
Sci Transl Med
. 2024 Sep;
16(763):eadh3172.
PMID: 39231241
Mechanistically targeted behavioral interventions are a much-needed strategy for improving outcomes in depression, especially for vulnerable populations with comorbidities such as obesity. Such interventions may change behavior and outcome by...
5.
Pines A, Tozzi L, Bertrand C, Keller A, Zhang X, Whitfield-Gabrieli S, et al.
JAMA Psychiatry
. 2024 Aug;
81(12):1236-1245.
PMID: 39196567
Importance: Mental illnesses are a leading cause of disability globally, and functional disability is often in part caused by cognitive impairments across psychiatric disorders. However, studies have consistently reported seemingly...
6.
Tozzi L, Zhang X, Pines A, Olmsted A, Zhai E, Anene E, et al.
Nat Med
. 2024 Jun;
30(7):2076-2087.
PMID: 38886626
There is an urgent need to derive quantitative measures based on coherent neurobiological dysfunctions or 'biotypes' to enable stratification of patients with depression and anxiety. We used task-free and task-evoked...
7.
Song E, Tozzi L, Williams L
Biol Psychiatry
. 2024 Mar;
96(7):552-563.
PMID: 38552866
Although the lifetime burden due to major depressive disorder is increasing, we lack tools for selecting the most effective treatments for each patient. One-third to one-half of patients with major...
8.
Beckmann F, Gruber H, Seidenbecher S, Schirmer S, Metzger C, Tozzi L, et al.
Eur J Neurosci
. 2024 Jan;
59(7):1819-1832.
PMID: 38217400
The brain's default mode network (DMN) and the executive control network (ECN) switch engagement are influenced by the ventral attention network (VAN). Alterations in resting-state functional connectivity (RSFC) within this...
9.
Huth F, Tozzi L, Marxen M, Riedel P, Brockel K, Martini J, et al.
Brain Sci
. 2023 Jun;
13(6).
PMID: 37371350
The pathophysiology of bipolar disorder (BD) remains mostly unclear. Yet, a valid biomarker is necessary to improve upon the early detection of this serious disorder. Patients with manifest BD display...
10.
Tuzhilina E, Tozzi L, Hastie T
Stat Modelling
. 2023 Jun;
23(3):203-227.
PMID: 37334164
Canonical correlation analysis (CCA) is a technique for measuring the association between two multivariate data matrices. A regularized modification of canonical correlation analysis (RCCA) which imposes an penalty on the...