Leanne M Williams
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Explore the profile of Leanne M Williams including associated specialties, affiliations and a list of published articles.
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326
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Recent Articles
1.
Williams L, Yesavage J
Pers Med Psychiatry
. 2025 Mar;
45-46.
PMID: 40066316
Background: We previously identified a cognitive biotype of depression characterized by dysfunction of the brain's cognitive control circuit, comprising the dorsolateral prefrontal cortex (dLPFC) and dorsal anterior cingulate cortex (dACC),...
2.
Park H, Egan L, Chilver M, Schofield P, Williams L, Gatt J
J Psychiatr Res
. 2025 Jan;
182:166-176.
PMID: 39813961
Early life stress (ELS) significantly influences mental health in later stages of life. Yet it is unclear whether recent life events lessen or intensify the effects of ELS on present...
3.
Akiki T, Jubeir J, Bertrand C, Tozzi L, Williams L
Nat Rev Neurosci
. 2024 Nov;
26(1):5-22.
PMID: 39604513
Anxiety disorders are the most prevalent mental health conditions worldwide. Unfortunately, the understanding of the precise neurobiological mechanisms that underlie these disorders remains limited. Current diagnostic classifications, based on observable...
4.
Bryant R, Breukelaar I, Williamson T, Felmingham K, Williams L, Korgaonkar M
Nat Ment Health
. 2024 Nov;
2(11):1342-1349.
PMID: 39525802
Although suicide risk is a major public health issue, attempts to understand the neural basis of suicidality have been limited by small sample sizes and a focus on specific psychiatric...
5.
Kas M, Hyman S, Williams L, Hidalgo-Mazzei D, Huys Q, Hotopf M, et al.
Eur Neuropsychopharmacol
. 2024 Sep;
90:16-27.
PMID: 39341044
Current nosology claims to separate mental disorders into distinct categories that do not overlap with each other. This nosological separation is not based on underlying pathophysiology but on convention-based clustering...
6.
Zhang X, Pines A, Stetz P, Goldstein-Piekarski A, Xiao L, Lv N, et al.
Sci Transl Med
. 2024 Sep;
16(763):eadh3172.
PMID: 39231241
Mechanistically targeted behavioral interventions are a much-needed strategy for improving outcomes in depression, especially for vulnerable populations with comorbidities such as obesity. Such interventions may change behavior and outcome by...
7.
Pines A, Tozzi L, Bertrand C, Keller A, Zhang X, Whitfield-Gabrieli S, et al.
JAMA Psychiatry
. 2024 Aug;
81(12):1236-1245.
PMID: 39196567
Importance: Mental illnesses are a leading cause of disability globally, and functional disability is often in part caused by cognitive impairments across psychiatric disorders. However, studies have consistently reported seemingly...
8.
9.
Williams L, Whitfield Gabrieli S
Neuropsychopharmacology
. 2024 Jul;
50(1):246-257.
PMID: 39039140
Although the lifetime burden due to mental disorders is increasing, we lack tools for more precise diagnosing and treating prevalent and disabling disorders such as major depressive disorder. We lack...
10.
Tozzi L, Zhang X, Pines A, Olmsted A, Zhai E, Anene E, et al.
Nat Med
. 2024 Jun;
30(7):2076-2087.
PMID: 38886626
There is an urgent need to derive quantitative measures based on coherent neurobiological dysfunctions or 'biotypes' to enable stratification of patients with depression and anxiety. We used task-free and task-evoked...