Leike Zhang
Overview
Explore the profile of Leike Zhang including associated specialties, affiliations and a list of published articles.
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65
Citations
6636
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Recent Articles
1.
Cao J, Zhang H, Zhang J, Wang J, Li C, Ma J, et al.
Antiviral Res
. 2025 Feb;
237:106105.
PMID: 39956272
Human adenovirus (HAdV) is a significant viral pathogen that causes severe acute respiratory infections (SARIs) in children and immunocompromised patients. Currently, no specific treatment options are available for HAdV infections....
2.
Chen J, Mu J, Zhou K, Zhang Y, Zhang J, Shu T, et al.
Mol Ther
. 2024 Dec;
33(1):201-214.
PMID: 39663700
Infections caused by coronaviruses are persistent threats to human health in recent decades, necessitating the development of innovative anti-coronaviral therapies. RNA interference (RNAi) is a conserved cell-intrinsic antiviral mechanism in...
3.
Han S, Ye X, Yang J, Peng X, Jiang X, Li J, et al.
Cell Chem Biol
. 2024 Nov;
31(12):2052-2068.e11.
PMID: 39566509
Lipids and lipid metabolism play an important role in RNA virus replication, which typically occurs on host cell endomembrane structures in the cytoplasm through mechanisms that are not yet fully...
4.
Deng W, Hu X, Tian X, Zhang Y, Shang W, Zhang L, et al.
J Med Chem
. 2024 Sep;
67(19):17124-17143.
PMID: 39292661
Cathepsin L (CatL) is a promising antiviral drug target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as an important protease for cleaving the SARS-CoV-2 spike protein and enhancing viral...
5.
Lu J, Cheng Y, Zhang Y, Wang Y, Xia B, Zhang L, et al.
Bioorg Med Chem Lett
. 2024 Sep;
113:129951.
PMID: 39251112
Here, we report the synthesis of a series of oxyacanthine derivatives and evaluation for their anti-SARS-CoV-2 activity in Vero E6 cells. In order to eliminate the potential metabolic activation caused...
6.
Jiang Z, Feng B, Chen L, Nie T, Chen S, Wang L, et al.
J Med Chem
. 2024 Jul;
67(15):12760-12783.
PMID: 39072488
SARS-CoV-2 has still been threatening global public health with its emerging variants. Our previous work reported lead compound that displayed good 3CL inhibitory activity. Here, an in-depth structural optimization for...
7.
Zheng M, Feng B, Zhang Y, Liu X, Zhao N, Liu H, et al.
Acta Pharm Sin B
. 2024 Jul;
14(7):3286-3290.
PMID: 39027261
No abstract available.
8.
Bie Y, Zhang J, Chen J, Zhang Y, Huang M, Zhang L, et al.
Virol Sin
. 2024 May;
39(4):645-654.
PMID: 38734183
The increasing emergence and re-emergence of RNA virus outbreaks underlines the urgent need to develop effective antivirals. RNA interference (RNAi) is a sequence-specific gene silencing mechanism that is triggered by...
9.
Xie X, Lan Q, Zhao J, Zhang S, Liu L, Zhang Y, et al.
Signal Transduct Target Ther
. 2024 Mar;
9(1):54.
PMID: 38443334
Respiratory disease caused by coronavirus infection remains a global health crisis. Although several SARS-CoV-2-specific vaccines and direct-acting antivirals are available, their efficacy on emerging coronaviruses in the future, including SARS-CoV-2...
10.
Cao B, Wang Y, Lu H, Huang C, Yang Y, Shang L, et al.
N Engl J Med
. 2024 Jan;
390(3):230-241.
PMID: 38231624
Background: Simnotrelvir is an oral 3-chymotrypsin-like protease inhibitor that has been found to have in vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and potential efficacy in a...