Layton H Smith
Overview
Explore the profile of Layton H Smith including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
40
Citations
870
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Alfonso E, Deng Z, Boaretto D, Hood B, Vasile S, Smith L, et al.
ACS Pharmacol Transl Sci
. 2022 Oct;
5(10):932-944.
PMID: 36268121
Bacterial DNA gyrase, a type IIA DNA topoisomerase that plays an essential role in bacterial DNA replication and transcription, is a clinically validated target for discovering and developing new antibiotics....
2.
Haass-Koffler C, Francis T, Gandhi P, Patel R, Naemuddin M, Nielsen C, et al.
SLAS Discov
. 2022 Oct;
27(8):448-459.
PMID: 36210051
Background: Stress responses are believed to involve corticotropin releasing factor (CRF), its two cognate receptors (CRF and CRF), and the CRF-binding protein (CRFBP). Whereas decades of research has focused on...
3.
Finneran D, Li Q, Subbarayan M, Joly-Amado A, Kamath S, Dengler D, et al.
Glia
. 2022 Sep;
71(2):245-258.
PMID: 36106533
Fractalkine (FKN) is a membrane-bound chemokine that can be cleaved by proteases such as ADAM 10, ADAM 17, and cathepsin S to generate soluble fragments. Studies using different forms of...
4.
Pinkerton A, Sessions E, Hershberger P, Maloney P, Peddibhotla S, Hopf M, et al.
Bioorg Med Chem Lett
. 2021 Apr;
41:128007.
PMID: 33798699
NAD is a crucial cellular factor that plays multifaceted roles in wide ranging biological processes. Low levels of NAD have been linked to numerous diseases including metabolic disorders, cardiovascular disease,...
5.
Peddibhotla S, Hershberger P, Kirby R, Sugarman E, Maloney P, Sessions E, et al.
Bioorg Med Chem Lett
. 2019 Dec;
30(4):126899.
PMID: 31882297
The chemokine system plays an important role in mediating a proinflammatory microenvironment for tumor growth in hepatocellular carcinoma (HCC). The CXCR6 receptor and its natural ligand CXCL16 are expressed at...
6.
Pinkerton A, Peddibhotla S, Yamamoto F, Slosky L, Bai Y, Maloney P, et al.
J Med Chem
. 2019 Aug;
62(17):8357-8363.
PMID: 31390201
Neurotensin receptor 1 (NTR1) is a G protein coupled receptor that is widely expressed throughout the central nervous system where it acts as a neuromodulator. Neurotensin receptors have been implicated...
7.
Morfa C, Bassoni D, Szabo A, McAnally D, Sharir H, Hood B, et al.
Assay Drug Dev Technol
. 2018 Sep;
16(7):384-396.
PMID: 30251873
G-protein-coupled receptors (GPCRs) have varying and diverse physiological roles, transmitting signals from a range of stimuli, including light, chemicals, peptides, and mechanical forces. More than 130 GPCRs are orphan receptors...
8.
McAnally D, Siddiquee K, Gomaa A, Szabo A, Vasile S, Maloney P, et al.
PLoS One
. 2018 Sep;
13(9):e0202436.
PMID: 30208056
Neovascularization is the pathological driver of blinding eye diseases such as retinopathy of prematurity, proliferative diabetic retinopathy, and wet age-related macular degeneration. The loss of vision resulting from these diseases...
9.
Rai R, Ghosh A, Eren M, Mackie A, Levine D, Kim S, et al.
Cell Rep
. 2017 Nov;
21(6):1471-1480.
PMID: 29117554
Aging drives the occurrence of numerous diseases, including cardiovascular disease (CVD). Recent studies indicate that blood from young mice reduces age-associated pathologies. However, the "anti-aging" factors in juvenile circulation remain...
10.
Kirby R, Divlianska D, Whig K, Bryan N, Morfa C, Koo A, et al.
J Pharmacol Exp Ther
. 2017 Nov;
364(1):87-96.
PMID: 29101218
Oxidative injury to cardiomyocytes plays a critical role in cardiac pathogenesis following myocardial infarction. Transplantation of stem cell-derived cardiomyocytes has recently progressed as a novel treatment to repair damaged cardiac...