Arianna Mangravita-Novo
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Explore the profile of Arianna Mangravita-Novo including associated specialties, affiliations and a list of published articles.
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15
Citations
247
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Recent Articles
1.
Khan A, El-Sayed A, Akbar A, Mangravita-Novo A, Bibi S, Afzal Z, et al.
Plant Methods
. 2017 Oct;
13:86.
PMID: 29075312
Background: Most current methods for constructing guide RNAs (gRNA) for the CRISPR/Cas9 genome editing system, depend on traditional cloning using specific type IIS restriction enzymes and DNA ligation. These methods...
2.
Peddibhotla S, Fontaine P, Leung C, Maloney P, Hershberger P, Wang Y, et al.
ACS Chem Biol
. 2015 May;
10(8):1871-9.
PMID: 25946346
Nematodes parasitize ∼1/3 of humans worldwide, and effective treatment via administration of anthelmintics is threatened by growing resistance to current therapies. The nematode transcription factor SKN-1 is essential for development...
3.
Bocsanczy A, Achenbach U, Mangravita-Novo A, Chow M, Norman D
BMC Genomics
. 2014 Apr;
15:280.
PMID: 24725348
Background: Ralstonia solanacearum, the causal agent of bacterial wilt, is a genetically diverse bacterial plant pathogen present in tropical and subtropical regions of the world that infects more than 200...
4.
Peddibhotla S, Hedrick M, Hershberger P, Maloney P, Li Y, Milewski M, et al.
ACS Med Chem Lett
. 2014 Mar;
4(9):846-851.
PMID: 24611085
The neurotensin 1 receptor (NTR1) is an important therapeutic target for a range of disease states including addiction. A high throughput screening campaign, followed by medicinal chemistry optimization, led to...
5.
Hershberger P, Hedrick M, Peddibhotla S, Mangravita-Novo A, Gosalia P, Li Y, et al.
Bioorg Med Chem Lett
. 2013 Dec;
24(1):262-7.
PMID: 24332089
A scaffold-hop program seeking full agonists of the neurotensin-1 (NTR1) receptor identified the probe molecule ML301 (1) and associated analogs, including its naphthyl analog (14) which exhibited similar properties. Compound...
6.
Sidique S, Dhanya R, Sheffler D, Nickols H, Yang L, Dahl R, et al.
J Med Chem
. 2012 Sep;
55(22):9434-45.
PMID: 23009245
Compounds that modulate metabotropic glutamate subtype 2 (mGlu(2)) receptors have the potential to treat several disorders of the central nervous system (CNS) including drug dependence. Herein we describe the synthesis...
7.
Preuss J, Maloney P, Peddibhotla S, Hedrick M, Hershberger P, Gosalia P, et al.
J Med Chem
. 2012 Jul;
55(16):7262-72.
PMID: 22813531
A high-throughput screen of the NIH's MLSMR collection of ∼340000 compounds was undertaken to identify compounds that inhibit Plasmodium falciparum glucose-6-phosphate dehydrogenase (PfG6PD). PfG6PD is important for proliferating and propagating...
8.
Frankowski K, Hedrick M, Gosalia P, Li K, Shi S, Whipple D, et al.
ACS Chem Neurosci
. 2012 Jun;
3(3):221-236.
PMID: 22737280
Herein we present the outcome of a high throughput screening (HTS) campaign-based strategy for the rapid identification and optimization of selective and general chemotypes for both kappa (κ) opioid receptor...
9.
Preuss J, Hedrick M, Sergienko E, Pinkerton A, Mangravita-Novo A, Smith L, et al.
J Biomol Screen
. 2012 Apr;
17(6):738-51.
PMID: 22496096
Plasmodium falciparum causes severe malaria infections in millions of people every year. The parasite is developing resistance to the most common antimalarial drugs, which creates an urgent need for new...
10.
Khan P, Correa R, Divlianska D, Peddibhotla S, Sessions E, Magnuson G, et al.
ACS Med Chem Lett
. 2011 Oct;
2(10):780-785.
PMID: 22003428
NOD1 (nucleotide-binding oligomerization domain 1) protein is a member of the NLR (NACHT and leucine rich repeat domain containing proteins) protein family, which plays a key role in innate immunity...