Laxminarayanan Krishnan
Overview
Explore the profile of Laxminarayanan Krishnan including associated specialties, affiliations and a list of published articles.
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35
Citations
708
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Recent Articles
1.
Priddy L, Krishnan L, Hettiaratchi M, Karthikeyakannan S, Gupte N, Guldberg R
J Orthop Res
. 2022 Mar;
41(1):130-140.
PMID: 35340049
Treatment of large bone defects with supraphysiological doses of bone morphogenetic protein-2 (BMP-2) has been associated with complications including heterotopic ossification (HO), inflammation, and pain, presumably due to poor spatiotemporal...
2.
Cheng A, Vantucci C, Krishnan L, Ruehle M, Kotanchek T, Wood L, et al.
Proc Natl Acad Sci U S A
. 2021 Feb;
118(8).
PMID: 33597299
Severe traumatic injuries are a widespread and challenging clinical problem, and yet the factors that drive successful healing and restoration of function are still not well understood. One recently identified...
3.
Strobel H, LaBelle S, Krishnan L, Dale J, Rauff A, Poulson 4th A, et al.
Front Physiol
. 2020 Oct;
11:1026.
PMID: 33013445
Vascular connectivity between adjacent vessel beds within and between tissue compartments is essential to any successful neovascularization process. To establish new connections, growing neovessels must locate other vascular elements during...
4.
Hettiaratchi M, Krishnan L, Rouse T, Chou C, McDevitt T, Guldberg R
Sci Adv
. 2020 Jan;
6(1):eaay1240.
PMID: 31922007
Supraphysiologic doses of bone morphogenetic protein-2 (BMP-2) are used clinically to promote bone formation in fracture nonunions, large bone defects, and spinal fusion. However, abnormal bone formation (i.e., heterotopic ossification)...
5.
Southern W, Nichenko A, Tehrani K, McGranahan M, Krishnan L, Qualls A, et al.
Sci Rep
. 2019 Mar;
9(1):4079.
PMID: 30858541
Volumetric muscle loss (VML) injury is characterized by a non-recoverable loss of muscle fibers due to ablative surgery or severe orthopaedic trauma, that results in chronic functional impairments of the...
6.
The Effects of Age and Dose on Gene Expression and Segmental Bone Defect Repair After BMP-2 Delivery
Cheng A, Krishnan L, Tran L, Stevens H, Xia B, Lee N, et al.
JBMR Plus
. 2019 Mar;
3(2):e10068.
PMID: 30828685
Age is a well-known influential factor in bone healing, with younger patients generally healing bone fractures more rapidly and suffering fewer complications compared with older patients. Yet the impact age...
7.
Ruehle M, Li M, Cheng A, Krishnan L, Willett N, Guldberg R
Acta Biomater
. 2019 Jan;
93:210-221.
PMID: 30685477
Traumatic musculoskeletal injuries that result in bone defects or fractures often affect both bone and the surrounding soft tissue. Clinically, these types of multi-tissue injuries have increased rates of complications...
8.
Ruehle M, Krishnan L, Vantucci C, Wang Y, Stevens H, Roy K, et al.
J Orthop Res
. 2019 Jan;
37(3):553-561.
PMID: 30648751
Traumatic composite bone-muscle injuries, such as open fractures, often require multiple surgical interventions and still typically result in long-term disability. Clinically, a critical indicator of composite injury severity is vascular...
9.
Cheng A, Krishnan L, Pradhan P, Weinstock L, Wood L, Roy K, et al.
J Orthop Res
. 2018 Nov;
37(2):299-307.
PMID: 30480339
Delayed union and nonunion are a significant concern in long bone fractures and spinal fusions. Treatment of nonunion often entails multiple revision surgeries that further increase the financial, physical, and...
10.
Ruehle M, Krishnan L, LaBelle S, Willett N, Weiss J, Guldberg R
MRS Commun
. 2018 Feb;
7(3):466-471.
PMID: 29450108
Angiogenesis is a critical component during wound healing, and the process is sensitive to mechanical stimuli. Current culture environments used to investigate three-dimensional microvascular growth often lack dimensional stability and...