Decorin-containing Collagen Hydrogels As Dimensionally Stable Scaffolds to Study the Effects of Compressive Mechanical Loading on Angiogenesis

Overview

Journal MRS Commun

Publisher Cambridge University Press

Date 2018 Feb 17

PMID 29450108

Citations 4

Authors

Marissa A Ruehle

Laxminarayanan Krishnan

Steven A LaBelle

Nick J Willett

Jeffrey A Weiss

Robert E Guldberg

Affiliations

Soon will be listed here.

Abstract

Angiogenesis is a critical component during wound healing, and the process is sensitive to mechanical stimuli. Current culture environments used to investigate three-dimensional microvascular growth often lack dimensional stability and the ability to withstand compression. We investigated the ability of decorin, a proteoglycan known to modulate collagen fibrillogenesis, incorporated into a collagen hydrogel to increase construct dimensional stability while maintaining vascular growth. Decorin did not affect microvascular growth parameters, while increasing the compressive modulus of collagen gels and significantly reducing the contraction of 3% collagen gels after 16 days in culture.

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