Laura M Selfors
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Explore the profile of Laura M Selfors including associated specialties, affiliations and a list of published articles.
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42
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Recent Articles
1.
Ueda Y, Kiyonaka S, Selfors L, Inoue K, Harada H, Doura T, et al.
Nat Cell Biol
. 2025 Feb;
27(3):530-543.
PMID: 39984655
Intratumour heterogeneity represents the hierarchical integration of genetic, phenotypic and microenvironmental heterogeneity. Although single-cell sequencing has clarified genetic and phenotypic variability, the heterogeneity of nongenetic, microenvironmental factors remains elusive. Here,...
2.
Kozlova N, Cruz K, Doh H, Ruzette A, Willis N, Hong S, et al.
bioRxiv
. 2025 Feb;
PMID: 39896456
Summary Paragraph: Drug resistance is a severe clinical problem in stroma-rich tumours, such as pancreatic ductal adenocarcinoma (PDAC), and patients often relapse within a few months on chemotherapy . The...
3.
Li C, Cordes A, Oliphant M, Quinn S, Thomas M, Selfors L, et al.
Nat Genet
. 2024 Nov;
56(12):2842.
PMID: 39567749
No abstract available.
4.
Li C, Cordes A, Oliphant M, Quinn S, Thomas M, Selfors L, et al.
Nat Genet
. 2024 Nov;
56(12):2763-2775.
PMID: 39528827
Germline BRCA1 mutation carriers face a high breast cancer risk; however, the underlying mechanisms for this risk are not completely understood. Using a new genetically engineered mouse model of germline...
5.
Asantewaa G, Tuttle E, Ward N, Kang Y, Kim Y, Kavanagh M, et al.
Nat Commun
. 2024 Jul;
15(1):6152.
PMID: 39034312
Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is...
6.
Hogstrom J, Cruz K, Selfors L, Ward M, Mehta T, Kanarek N, et al.
J Biol Chem
. 2023 Jul;
299(8):105021.
PMID: 37423299
Recurrent hormone receptor-positive (HR+) breast cancer kills more than 600,000 women annually. Although HR+ breast cancers typically respond well to therapies, approximately 30% of patients relapse. At this stage, the...
7.
Asantewaa G, Tuttle E, Ward N, Kang Y, Kim Y, Kavanagh M, et al.
bioRxiv
. 2023 Feb;
PMID: 36798186
Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is...
8.
Gray G, Li C, Rosenbluth J, Selfors L, Girnius N, Lin J, et al.
Dev Cell
. 2022 May;
57(11):1400-1420.e7.
PMID: 35617956
The breast is a dynamic organ whose response to physiological and pathophysiological conditions alters its disease susceptibility, yet the specific effects of these clinical variables on cell state remain poorly...
9.
Choi B, Rawat V, Hogstrom J, Burns P, Conger K, Ozgurses M, et al.
Cell Rep
. 2022 Jan;
38(3):110278.
PMID: 35045283
A major challenge of targeting metabolism for cancer therapy is pathway redundancy, in which multiple sources of critical nutrients can limit the effectiveness of some metabolism-targeted therapies. Here, we analyze...
10.
Kuiken H, Dhakal S, Selfors L, Friend C, Zhang T, Callari M, et al.
Oncogene
. 2021 Oct;
41(1):112-124.
PMID: 34703030
Intratumoral heterogeneity has been described for various tumor types and models of human cancer, and can have profound effects on tumor progression and drug resistance. This study describes an in-depth...