Jonathan L Coloff
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Explore the profile of Jonathan L Coloff including associated specialties, affiliations and a list of published articles.
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41
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2775
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Recent Articles
1.
Hecht F, Zocchi M, Tuttle E, Ward N, Smith B, Kang Y, et al.
bioRxiv
. 2024 Oct;
PMID: 39416022
Restricting amino acids from tumors is an emerging therapeutic strategy with significant promise. While typically considered an intracellular antioxidant with tumor-promoting capabilities, glutathione (GSH) is a tripeptide of cysteine, glutamate,...
2.
Conger K, Chidley C, Ozgurses M, Zhao H, Kim Y, Semina S, et al.
Cell Rep
. 2024 Jul;
43(8):114552.
PMID: 39068660
The non-essential amino acid serine is a critical nutrient for cancer cells due to its diverse biosynthetic functions. While some tumors can synthesize serine de novo, others are auxotrophic and...
3.
Rawat V, DeLear P, Prashanth P, Ozgurses M, Tebeje A, Burns P, et al.
JCI Insight
. 2024 May;
9(13).
PMID: 38815134
The nonphysiological nutrient levels found in traditional culture media have been shown to affect numerous aspects of cancer cell physiology, including how cells respond to certain therapeutic agents. Here, we...
4.
Conger K, Chidley C, Ozgurses M, Zhao H, Kim Y, Semina S, et al.
bioRxiv
. 2023 Oct;
PMID: 37873453
The non-essential amino acid serine is a critical nutrient for cancer cells due to its diverse biosynthetic functions. While some tumors can synthesize serine , others are auxotrophic for serine...
5.
Rawat V, DeLear P, Prashanth P, Ozgurses M, Tebeje A, Burns P, et al.
bioRxiv
. 2023 Aug;
PMID: 37546939
The non-physiological nutrient levels found in traditional culture media have been shown to affect numerous aspects of cancer cell physiology, including how cells respond to certain therapeutic agents. Here, we...
6.
de Wet L, Williams A, Gillard M, Kregel S, Lamperis S, Gutgesell L, et al.
Oncogene
. 2022 Feb;
41(8):1234.
PMID: 35145235
No abstract available.
7.
de Wet L, Williams A, Gillard M, Kregel S, Lamperis S, Gutgesell L, et al.
Oncogene
. 2022 Jan;
41(8):1190-1202.
PMID: 35067686
New strategies are needed to predict and overcome metastatic progression and therapy resistance in prostate cancer. One potential clinical target is the stem cell transcription factor SOX2, which has a...
8.
Choi B, Rawat V, Hogstrom J, Burns P, Conger K, Ozgurses M, et al.
Cell Rep
. 2022 Jan;
38(3):110278.
PMID: 35045283
A major challenge of targeting metabolism for cancer therapy is pathway redundancy, in which multiple sources of critical nutrients can limit the effectiveness of some metabolism-targeted therapies. Here, we analyze...
9.
Keibler M, Dong W, Korthauer K, Hosios A, Moon S, Sullivan L, et al.
FEBS J
. 2021 Apr;
288(19):5629-5649.
PMID: 33811729
Many metabolic phenotypes in cancer cells are also characteristic of proliferating nontransformed mammalian cells, and attempts to distinguish between phenotypes resulting from oncogenic perturbation from those associated with increased proliferation...
10.
Kang Y, Falzone A, Liu M, Gonzalez-Sanchez P, Choi B, Coloff J, et al.
Cancer Metab
. 2020 Jun;
8:6.
PMID: 32549981
Background: d-3-phosphoglycerate dehydrogenase (PHGDH), which encodes the first enzyme in serine biosynthesis, is overexpressed in human cancers and has been proposed as a drug target. However, whether PHGDH is critical...