G Kenneth Gray
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Explore the profile of G Kenneth Gray including associated specialties, affiliations and a list of published articles.
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17
Citations
542
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Recent Articles
1.
Girnius N, Henstridge A, Marks B, Yu J, Gray G, Sander C, et al.
Breast Cancer Res
. 2024 Dec;
26(1):187.
PMID: 39707454
Background: Treatment options for triple-negative breast cancer (TNBC) are limited and patients face a poor prognosis. Here, we sought to identify drugs that target TNBC vulnerabilities and understand the biology...
2.
Asantewaa G, Tuttle E, Ward N, Kang Y, Kim Y, Kavanagh M, et al.
Nat Commun
. 2024 Jul;
15(1):6152.
PMID: 39034312
Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is...
3.
Gray G, Girnius N, Kuiken H, Henstridge A, Brugge J
Cell Rep
. 2023 Oct;
42(10):113293.
PMID: 37858468
Although distinct epithelial cell types have been distinguished in glandular tissues such as the mammary gland, the extent of heterogeneity within each cell type and the degree of endocrine control...
4.
Najafabadi M, Gray G, Kong L, Gupta K, Perera D, Naylor H, et al.
Nat Commun
. 2023 Aug;
14(1):5206.
PMID: 37626143
Germline BRCA2 mutation carriers frequently develop luminal-like breast cancers, but it remains unclear how BRCA2 mutations affect mammary epithelial subpopulations. Here, we report that monoallelic Brca2 mammary organoids subjected to...
5.
Bergholz J, Wang Q, Wang Q, Ramseier M, Prakadan S, Wang W, et al.
Nature
. 2023 Apr;
617(7959):139-146.
PMID: 37076617
Loss of the PTEN tumour suppressor is one of the most common oncogenic drivers across all cancer types. PTEN is the major negative regulator of PI3K signalling. The PI3Kβ isoform...
6.
Asantewaa G, Tuttle E, Ward N, Kang Y, Kim Y, Kavanagh M, et al.
bioRxiv
. 2023 Feb;
PMID: 36798186
Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is...
7.
Gray G, Li C, Rosenbluth J, Selfors L, Girnius N, Lin J, et al.
Dev Cell
. 2022 May;
57(11):1400-1420.e7.
PMID: 35617956
The breast is a dynamic organ whose response to physiological and pathophysiological conditions alters its disease susceptibility, yet the specific effects of these clinical variables on cell state remain poorly...
8.
Meng Q, Xie S, Gray G, Dezfulian M, Li W, Huang L, et al.
J Immunother Cancer
. 2021 Nov;
9(11).
PMID: 34789550
Background: Tumor-specific cytotoxic T cells and T cell receptors are effective tools for cancer immunotherapy. Most efforts to identify them rely on known antigens or lymphocytes that have infiltrated into...
9.
Kuiken H, Dhakal S, Selfors L, Friend C, Zhang T, Callari M, et al.
Oncogene
. 2021 Oct;
41(1):112-124.
PMID: 34703030
Intratumoral heterogeneity has been described for various tumor types and models of human cancer, and can have profound effects on tumor progression and drug resistance. This study describes an in-depth...
10.
Li C, Shapiro H, Tsiobikas C, Selfors L, Chen H, Rosenbluth J, et al.
Cell Rep
. 2020 Dec;
33(13):108566.
PMID: 33378681
Aging is closely associated with increased susceptibility to breast cancer, yet there have been limited systematic studies of aging-induced alterations in the mammary gland. Here, we leverage high-throughput single-cell RNA...