Laura A Borrelli
Overview
Explore the profile of Laura A Borrelli including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
264
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0
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Recent Articles
1.
Garcia-Alloza M, Borrelli L, Thyssen D, Hickman S, El Khoury J, Bacskai B
Intravital
. 2017 Sep;
2(2).
PMID: 28944103
Senile plaques, mainly composed of amyloid-β (Aβ), are a major hallmark of Alzheimer disease (AD), and immunotherapy is a leading therapeutic approach for Aβ clearance. Although the ultimate mechanisms for...
2.
Xie H, Guan J, Borrelli L, Xu J, Serrano-Pozo A, Bacskai B
J Neurosci
. 2013 Oct;
33(43):17042-51.
PMID: 24155308
While accumulation of amyloid-β (Aβ) deposited as senile plaques is a hallmark feature of Alzheimer's disease (AD), the neurotoxicity of these deposits remains controversial. Recent in vitro studies suggested a...
3.
Garcia-Alloza M, Prada C, Lattarulo C, Fine S, Borrelli L, Betensky R, et al.
J Neurochem
. 2009 May;
109(6):1636-47.
PMID: 19457117
Cerebral amyloid angiopathy (CAA), characterized by extracellular beta-amyloid peptide (Abeta) deposits in vessel walls, is present in the majority of cases of Alzheimer's disease and is a major cause of...
4.
Garcia-Alloza M, Subramanian M, Thyssen D, Borrelli L, Fauq A, Das P, et al.
Mol Neurodegener
. 2009 May;
4:19.
PMID: 19419556
The gamma-secretase complex is a major therapeutic target for the prevention and treatment of Alzheimer's disease. Previous studies have shown that treatment of young APP mice with specific inhibitors of...
5.
Garcia-Alloza M, Borrelli L, Hyman B, Bacskai B
Neurobiol Aging
. 2009 Jan;
31(12):2058-68.
PMID: 19124175
Senile plaques are a major pathological hallmark of Alzheimer's disease (AD). Compelling evidence suggests that senile plaques lead to structural alterations of neuronal processes and that local toxicity may be...
6.
Jiang Y, Borrelli L, Kanaoka Y, Bacskai B, Boyce J
Blood
. 2007 Aug;
110(9):3263-70.
PMID: 17693579
Cysteinyl leukotrienes (cys-LTs) induce inflammation through 2 G protein-coupled receptors (GPCRs), CysLT(1) and CysLT(2), which are coexpressed by most myeloid cells. Cys-LTs induce proliferation of mast cells (MCs), transactivate c-Kit,...