Alberto Serrano-Pozo
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Explore the profile of Alberto Serrano-Pozo including associated specialties, affiliations and a list of published articles.
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68
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7113
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Recent Articles
1.
Serrano-Pozo A, Li H, Li Z, Munoz-Castro C, Jaisa-Aad M, Healey M, et al.
Nat Neurosci
. 2024 Nov;
27(12):2384-2400.
PMID: 39528672
Astrocytes are crucial to brain homeostasis, yet their changes along the spatiotemporal progression of Alzheimer's disease (AD) neuropathology remain unexplored. Here we performed single-nucleus RNA sequencing of 628,943 astrocytes from...
2.
Munoz-Castro C, Serrano-Pozo A
Adv Neurobiol
. 2024 Aug;
39:345-382.
PMID: 39190082
Besides its two defining misfolded proteinopathies-Aβ plaques and tau neurofibrillary tangles-Alzheimer's disease (AD) is an exemplar of a neurodegenerative disease with prominent reactive astrogliosis, defined as the set of morphological,...
3.
Jackson R, Melloni A, Fykstra D, Serrano-Pozo A, Shinobu L, Hyman B
Acta Neuropathol Commun
. 2024 Aug;
12(1):132.
PMID: 39138580
Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by 4R tau deposition in neurons as well as in astrocytes and oligodendrocytes. While astrocytic tau deposits are rarely observed in...
4.
Garma L, Harder L, Barba-Reyes J, Marco Salas S, Diez-Salguero M, Nilsson M, et al.
Nat Commun
. 2024 Jul;
15(1):6164.
PMID: 39039043
Deciphering the striatal interneuron diversity is key to understanding the basal ganglia circuit and to untangling the complex neurological and psychiatric diseases affecting this brain structure. We performed snRNA-seq and...
5.
Jackson R, Hyman B, Serrano-Pozo A
Nat Rev Neurol
. 2024 Jun;
20(8):457-474.
PMID: 38906999
For the past three decades, apolipoprotein E (APOE) has been known as the single greatest genetic modulator of sporadic Alzheimer disease (AD) risk, influencing both the average age of onset...
6.
Jaisa-Aad M, Munoz-Castro C, Healey M, Hyman B, Serrano-Pozo A
Acta Neuropathol
. 2024 Apr;
147(1):66.
PMID: 38568475
Reactive astrogliosis accompanies the two neuropathological hallmarks of Alzheimer's disease (AD)-Aβ plaques and neurofibrillary tangles-and parallels neurodegeneration in AD and AD-related dementias (ADRD). Thus, there is growing interest in developing...
7.
Wachter A, Woodbury M, Lombardo S, Abdourahman A, Wuest C, McGlame E, et al.
Acta Neuropathol
. 2024 Apr;
147(1):65.
PMID: 38557897
Human microglia are critically involved in Alzheimer's disease (AD) progression, as shown by genetic and molecular studies. However, their role in tau pathology progression in human brain has not been...
8.
Noori A, Jayakumar R, Moturi V, Li Z, Liu R, Serrano-Pozo A, et al.
J Alzheimers Dis
. 2024 Feb;
99(s2):S397-S407.
PMID: 38306039
Background: Recent Alzheimer's disease (AD) discoveries are increasingly based on studies from a variety of omics technologies on large cohorts. Currently, there is no easily accessible resource for neuroscientists to...
9.
Jaisa-Aad M, Munoz-Castro C, Serrano-Pozo A
Curr Opin Neurol
. 2024 Jan;
37(2):166-181.
PMID: 38265228
Purpose Of Review: All human beings undergo a lifelong cumulative exposure to potentially preventable adverse factors such as toxins, infections, traumatisms, and cardiovascular risk factors, collectively termed exposome. The interplay...
10.
Calvo-Rodriguez M, Kharitonova E, Snyder A, Hou S, Sanchez-Mico M, Das S, et al.
Mol Neurodegener
. 2024 Jan;
19(1):6.
PMID: 38238819
Background: Reactive oxidative stress is a critical player in the amyloid beta (Aβ) toxicity that contributes to neurodegeneration in Alzheimer's disease (AD). Damaged mitochondria are one of the main sources...