Lars Holmgren
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Explore the profile of Lars Holmgren including associated specialties, affiliations and a list of published articles.
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51
Citations
1501
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Recent Articles
1.
Zhang Y, Zhang Y, Hutterer E, Hultin S, Bergman O, Kolbeinsdottir S, et al.
Nat Cardiovasc Res
. 2024 Aug;
2(7):629-644.
PMID: 39195920
Endothelial cells respond to mechanical forces exerted by blood flow. Endothelial cell-cell junctions and the sites of endothelial adhesion to the matrix sense and transmit mechanical forces to the cellular...
2.
Fonseca P, Cui W, Struyf N, Tong L, Chaurasiya A, Casagrande F, et al.
J Exp Clin Cancer Res
. 2024 Apr;
43(1):107.
PMID: 38594748
Background: Tumor cells have the ability to invade and form small clusters that protrude into adjacent tissues, a phenomenon that is frequently observed at the periphery of a tumor as...
3.
Mannion A, Zhao H, Zhang Y, von Wright Y, Bergman O, Roy J, et al.
Arterioscler Thromb Vasc Biol
. 2024 Feb;
44(3):666-689.
PMID: 38299356
Background: Endothelial cells are constantly exposed to mechanical forces in the form of fluid shear stress, extracellular stiffness, and cyclic strain. The mechanoresponsive activity of YAP (Yes-associated protein) and its...
4.
Mannion A, Holmgren L
Dis Model Mech
. 2023 Nov;
16(10).
PMID: 37909406
The endothelium, the monolayer of endothelial cells that line blood vessels, is exposed to a number of mechanical forces, including frictional shear flow, pulsatile stretching and changes in stiffness influenced...
5.
Cui W, Subramani A, Fonseca P, Zhang Y, Tong L, Zhang Y, et al.
Cells
. 2023 Sep;
12(17).
PMID: 37681890
Preserving an accurate cell count is crucial for maintaining homeostasis. Apical extrusion, a process in which redundant cells are eliminated by neighboring cells, plays a key role in this regard....
6.
Subramani A, Cui W, Zhang Y, Friman T, Zhao Z, Huang W, et al.
Cells
. 2023 Jul;
12(13).
PMID: 37443716
The spread of tumor cells and the formation of distant metastasis remain the main causes of mortality in cancer patients. However, the mechanisms governing the release of cells from micro-environmental...
7.
Maeso-Alonso L, Alonso-Olivares H, Martinez-Garcia N, Lopez-Ferreras L, Villoch-Fernandez J, Puente-Santamaria L, et al.
Cell Mol Life Sci
. 2022 Sep;
79(10):535.
PMID: 36180740
Preservation of blood vessel integrity, which is critical for normal physiology and organ function, is controlled at multiple levels, including endothelial junctions. However, the mechanism that controls the adequate assembly...
8.
Zhang Y, Zhang Y, Kameishi S, Barutello G, Zheng Y, Tobin N, et al.
Cell Rep
. 2021 Aug;
36(8):109616.
PMID: 34433061
Vascular development is a complex multistep process involving the coordination of cellular functions such as migration, proliferation, and differentiation. How mechanical forces generated by cells and transmission of these physical...
9.
Yang Y, Neo S, Chen Z, Cui W, Chen Y, Guo M, et al.
J Clin Invest
. 2020 Jul;
130(10):5508-5522.
PMID: 32673292
To improve the clinical outcome of adoptive NK cell therapy in patients with solid tumors, NK cells need to persist within the tumor microenvironment (TME) in which the abundance of...
10.
Rojek K, Krzemien J, Dolezyczek H, Boguszewski P, Kaczmarek L, Konopka W, et al.
PLoS Biol
. 2019 May;
17(5):e3000253.
PMID: 31042703
The angiomotin (Amot)-Yes-associated protein 1 (Yap1) complex plays a major role in regulating the inhibition of cell contact, cellular polarity, and cell growth in many cell types. However, the function...