Lars E T Jansen
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Explore the profile of Lars E T Jansen including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
2745
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Recent Articles
11.
Murillo-Pineda M, Jansen L
Exp Cell Res
. 2020 Feb;
389(2):111909.
PMID: 32068000
The duplication and segregation of the genome during cell division is crucial to maintain cell identity, development of organisms and tissue maintenance. Centromeres are at the basis of accurate chromosome...
12.
Mitra S, Bodor D, David A, Abdul-Zani I, Mata J, Neumann B, et al.
Nat Commun
. 2020 Jan;
11(1):501.
PMID: 31980633
Centromeres are defined by a self-propagating chromatin structure based on stable inheritance of CENP-A containing nucleosomes. Here, we present a genetic screen coupled to pulse-chase labeling that allow us to...
13.
Stajic D, Perfeito L, Jansen L
Nat Ecol Evol
. 2019 Feb;
3(3):491-498.
PMID: 30718851
Epigenetic, non-DNA sequence-based inheritance can potentially contribute to adaptation but, due to its transient nature and the difficulty involved in uncoupling it from genetic variation, it is unclear whether it...
14.
Siwek W, Gomez-Rodriguez M, Sobral D, Correa Jr I, Jansen L
Methods Mol Biol
. 2018 Aug;
1832:131-158.
PMID: 30073525
Understanding chromatin dynamics is essential to define the contribution of chromatin to heritable gene silencing and the long-term maintenance of gene expression. Here we present a detailed protocol for time-ChIP,...
15.
Stankovic A, Jansen L
Prog Mol Subcell Biol
. 2017 Aug;
56:139-162.
PMID: 28840236
Centromeres are chromatin domains specified by nucleosomes containing the histone H3 variant, CENP-A. This unique centromeric structure is at the heart of a strong self-templating epigenetic mechanism that renders centromeres...
16.
Stankovic A, Guo L, Mata J, Bodor D, Cao X, Bailey A, et al.
Mol Cell
. 2016 Dec;
65(2):231-246.
PMID: 28017591
Chromatin featuring the H3 variant CENP-A at the centromere is critical for its mitotic function and epigenetic maintenance. Assembly of centromeric chromatin is restricted to G1 phase through inhibitory action...
17.
Falk S, Guo L, Sekulic N, Smoak E, Mani T, Logsdon G, et al.
Science
. 2015 May;
348(6235):699-703.
PMID: 25954010
Inheritance of each chromosome depends upon its centromere. A histone H3 variant, centromere protein A (CENP-A), is essential for epigenetically marking centromere location. We find that CENP-A is quantitatively retained...
18.
Fachinetti D, Folco H, Nechemia-Arbely Y, Valente L, Nguyen K, Wong A, et al.
Nat Cell Biol
. 2013 Jul;
15(9):1056-66.
PMID: 23873148
The basic determinant of chromosome inheritance, the centromere, is specified in many eukaryotes by an epigenetic mark. Using gene targeting in human cells and fission yeast, chromatin containing the centromere-specific...
19.
20.
Bodor D, Valente L, Mata J, Black B, Jansen L
Mol Biol Cell
. 2013 Feb;
24(7):923-32.
PMID: 23363600
Centromeres are the site of kinetochore formation during mitosis. Centromere protein A (CENP-A), the centromere-specific histone H3 variant, is essential for the epigenetic maintenance of centromere position. Previously we showed...