Larry D Mesner
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Explore the profile of Larry D Mesner including associated specialties, affiliations and a list of published articles.
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27
Citations
723
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Recent Articles
11.
Calabrese G, Mesner L, Stains J, Tommasini S, Horowitz M, Rosen C, et al.
Cell Syst
. 2016 Nov;
4(1):46-59.e4.
PMID: 27866947
Bone mineral density (BMD) is a highly heritable predictor of osteoporotic fracture. Genome-wide association studies (GWAS) for BMD have identified dozens of associations; yet, the genes responsible for most associations...
12.
Calabrese G, Mesner L, Foley P, Rosen C, Farber C
Sci Rep
. 2016 Jul;
6:29475.
PMID: 27378017
The postmenopausal period in women is associated with decreased circulating estrogen levels, which accelerate bone loss and increase the risk of fracture. Here, we gained novel insight into the molecular...
13.
Mesner L, Hamlin J
Methods Mol Biol
. 2015 Apr;
1300:279-92.
PMID: 25916718
The identification and isolation of origins of replication from mammalian genomes has been a demanding task owing to the great complexity of these genomes. However, two methods have been refined...
14.
Mesner L, Dijkwel P, Hamlin J
Methods Mol Biol
. 2015 Apr;
1300:261-77.
PMID: 25916717
In order to perform 2-D gel analyses on restriction fragments from higher eukaryotic genomes, it is necessary to remove most of the linear, nonreplicating, fragments from the starting DNA preparation....
15.
Mesner L, Ray B, Hsu Y, Manichaikul A, Lum E, Bryda E, et al.
J Clin Invest
. 2014 May;
124(6):2736-49.
PMID: 24789909
Patient bone mineral density (BMD) predicts the likelihood of osteoporotic fracture. While substantial progress has been made toward elucidating the genetic determinants of BMD, our understanding of the factors involved...
16.
Janbon G, Ormerod K, Paulet D, Byrnes 3rd E, Yadav V, Chatterjee G, et al.
PLoS Genet
. 2014 Apr;
10(4):e1004261.
PMID: 24743168
Cryptococcus neoformans is a pathogenic basidiomycetous yeast responsible for more than 600,000 deaths each year. It occurs as two serotypes (A and D) representing two varieties (i.e. grubii and neoformans,...
17.
Mesner L, Valsakumar V, Cieslik M, Pickin R, Hamlin J, Bekiranov S
Genome Res
. 2013 Jul;
23(11):1774-88.
PMID: 23861383
We have devised a method for isolating virtually pure and comprehensive libraries of restriction fragments that contained replication initiation sites (bubbles) in vivo. We have now sequenced and mapped the...
18.
Givens R, Mesner L, Hamlin J, Buck M, Huberman J
BMC Res Notes
. 2011 Nov;
4:499.
PMID: 22088094
Background: Studies of nuclear function in many organisms, especially those with tough cell walls, are limited by lack of availability of simple, economical methods for large-scale preparation of clean, undamaged...
19.
Mesner L, Valsakumar V, Karnani N, Dutta A, Hamlin J, Bekiranov S
Genome Res
. 2010 Dec;
21(3):377-89.
PMID: 21173031
We have used a novel bubble-trapping procedure to construct nearly pure and comprehensive human origin libraries from early S- and log-phase HeLa cells, and from log-phase GM06990, a karyotypically normal...
20.
Guasconi V, Pritchard L, Fritsch L, Mesner L, Francastel C, Harel-Bellan A, et al.
Epigenetics
. 2010 Aug;
5(8):704-9.
PMID: 20716953
The heterochromatin-associated H3K9 tri-methylase Suv39h1 is involved in the permanent silencing of E2F target genes in differentiating but not in quiescent cells. Here, we tested the hypothesis that permanent silencing...