Larry D Mesner
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Explore the profile of Larry D Mesner including associated specialties, affiliations and a list of published articles.
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27
Citations
723
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Recent Articles
1.
Abood A, Mesner L, Jeffery E, Murali M, Lehe M, Saquing J, et al.
Am J Hum Genet
. 2024 Jul;
111(9):1914-1931.
PMID: 39079539
A major fraction of loci identified by genome-wide association studies (GWASs) mediate alternative splicing, but mechanistic interpretation is hindered by the technical limitations of short-read RNA sequencing (RNA-seq), which cannot...
2.
Dillard L, Calabrese G, Mesner L, Farber C
bioRxiv
. 2024 Jun;
PMID: 38826475
Genome-wide association studies (GWASs) have identified many sources of genetic variation associated with bone mineral density (BMD), a clinical predictor of fracture risk and osteoporosis. Aside from the identification of...
3.
Dillard L, Rosenow W, Calabrese G, Mesner L, Al-Barghouthi B, Abood A, et al.
J Bone Miner Res
. 2023 Jul;
38(9):1350-1363.
PMID: 37436066
Genome-wide association studies (GWASs) have advanced our understanding of the genetics of osteoporosis; however, the challenge has been converting associations to causal genes. Studies have utilized transcriptomics data to link...
4.
Abood A, Mesner L, Jeffery E, Murali M, Lehe M, Saquing J, et al.
bioRxiv
. 2023 Mar;
PMID: 36993769
A major fraction of loci identified by genome-wide association studies (GWASs) lead to alterations in alternative splicing, but interpretation of how such alterations impact proteins is hindered by the technical...
5.
Moran M, Ko F, Mesner L, Calabrese G, Al-Barghouthi B, Farber C, et al.
Bone
. 2022 Aug;
164:116524.
PMID: 36028119
There are over one million cases of failed bone repair in the U.S. annually, resulting in substantial patient morbidity and societal costs. Multiple candidate genes affecting bone traits such as...
6.
Harp S, Martini M, Rosenow W, Mesner L, Johnson H, Farber C, et al.
Physiol Behav
. 2021 Oct;
243:113630.
PMID: 34710466
An increase in opioid-overdose deaths was evident before the COVID-19 pandemic, and has escalated since its onset. Fentanyl, a highly potent synthetic opioid, is the primary driver of these recent...
7.
Al-Barghouthi B, Mesner L, Calabrese G, Brooks D, Tommasini S, Bouxsein M, et al.
Nat Commun
. 2021 Jun;
12(1):3408.
PMID: 34099702
Genome-wide association studies (GWASs) for osteoporotic traits have identified over 1000 associations; however, their impact has been limited by the difficulties of causal gene identification and a strict focus on...
8.
Zhang Q, Mesner L, Calabrese G, Dirckx N, Li Z, Verardo A, et al.
J Clin Invest
. 2021 Apr;
131(7).
PMID: 33792563
Bone mineral density (BMD) is a highly heritable predictor of osteoporotic fracture. GWAS have identified hundreds of loci influencing BMD, but few have been functionally analyzed. In this study, we...
9.
Doolittle M, Calabrese G, Mesner L, Godfrey D, Maynard R, Ackert-Bicknell C, et al.
PLoS Genet
. 2020 Jun;
16(6):e1008805.
PMID: 32497039
Osteoporosis is a genetic disease characterized by progressive reductions in bone mineral density (BMD) leading to an increased risk of fracture. Over the last decade, genome-wide association studies (GWASs) have...
10.
Mesner L, Calabrese G, Al-Barghouthi B, Gatti D, Sundberg J, Churchill G, et al.
PLoS Genet
. 2019 May;
15(5):e1008123.
PMID: 31042701
Bone mineral density (BMD) is a strong predictor of osteoporotic fracture. It is also one of the most heritable disease-associated quantitative traits. As a result, there has been considerable effort...