Steven J Stout
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Explore the profile of Steven J Stout including associated specialties, affiliations and a list of published articles.
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14
Citations
181
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Recent Articles
1.
Wen X, Liu C, Ghislain L, Tovar K, Shah V, Stout S, et al.
Anal Chem
. 2021 Apr;
93(15):6071-6079.
PMID: 33819010
The primary goal of high-throughput screening (HTS) is to rapidly survey a broad collection of compounds, numbering from tens of thousands to millions of members, and identify those that modulate...
2.
McLaren D, Han S, Murphy B, Wilsie L, Stout S, Zhou H, et al.
Cell Metab
. 2018 May;
27(6):1236-1248.e6.
PMID: 29706567
Diacylglycerol acyltransferase 2 (DGAT2) catalyzes the final step in triglyceride (TG) synthesis and has been shown to play a role in regulating hepatic very-low-density lipoprotein (VLDL) production in rodents. To...
3.
Jensen K, Tadin-Strapps M, Wang S, Hubert J, Kan Y, Ma Y, et al.
J Lipid Res
. 2016 Oct;
57(12):2150-2162.
PMID: 27707816
SREBP cleavage-activating protein (SCAP) is a key protein in the regulation of lipid metabolism and a potential target for treatment of dyslipidemia. SCAP is required for activation of the transcription...
4.
Liu J, McLaren D, Chen D, Kan Y, Stout S, Shen X, et al.
Pharmacol Res Perspect
. 2016 Mar;
3(6):e00193.
PMID: 27022467
Studies have demonstrated that blockade of diacylglycerol acyltransferase 1 (DGAT1) leads to prolonged release of glucagon-like peptide 1 (GLP-1) after meal challenge. The current study was undertaken to investigate the...
5.
McLaren D, Previs S, Phair R, Stout S, Xie D, Chen Y, et al.
J Lipid Res
. 2015 Dec;
57(3):398-409.
PMID: 26658238
Studies in lipoprotein kinetics almost exclusively rely on steady-state approaches to modeling. Herein, we have used a non-steady-state experimental design to examine the role of cholesteryl ester transfer protein (CETP)...
6.
Imbriglio J, Shen D, Liang R, Marby K, You M, Youm H, et al.
J Med Chem
. 2015 Nov;
58(23):9345-53.
PMID: 26561979
DGAT2 plays a critical role in hepatic triglyceride production, and data suggests that inhibition of DGAT2 could prove to be beneficial in treating a number of disease states. This article...
7.
Marzinzik A, Amstutz R, Bold G, Bourgier E, Cotesta S, Glickman J, et al.
ChemMedChem
. 2015 Sep;
10(11):1884-91.
PMID: 26381451
Farnesyl pyrophosphate synthase (FPPS) is an established target for the treatment of bone diseases, but also shows promise as an anticancer and anti-infective drug target. Currently available anti-FPPS drugs are...
8.
Previs S, Herath K, Castro-Perez J, Mahsut A, Zhou H, McLaren D, et al.
Methods Enzymol
. 2015 Sep;
561:331-58.
PMID: 26358910
Stable isotope tracers are widely used to quantify metabolic rates, and yet a limited number of studies have considered the impact of analytical error on estimates of flux. For example,...
9.
Previs S, McLaren D, Wang S, Stout S, Zhou H, Herath K, et al.
Biochim Biophys Acta
. 2013 May;
1842(3):402-13.
PMID: 23707557
Our ability to understand the pathogenesis of problems surrounding lipid accretion requires attention towards quantifying lipid kinetics. In addition, studies of metabolic flux should also help unravel mechanisms that lead...
10.
McLaren D, Cardasis H, Stout S, Wang S, Mendoza V, Castro-Perez J, et al.
Anal Chem
. 2013 May;
85(13):6287-94.
PMID: 23668715
We have previously reported on a liquid chromatography-mass spectrometry method to determine the disposition of [(13)C18]-oleic acid following intravenous and oral administration in vivo. This approach has enabled us to...