Larissa Savelyeva
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Explore the profile of Larissa Savelyeva including associated specialties, affiliations and a list of published articles.
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28
Citations
694
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Recent Articles
1.
Hartlieb S, Sieverling L, Nadler-Holly M, Ziehm M, Toprak U, Herrmann C, et al.
Nat Commun
. 2021 Feb;
12(1):1269.
PMID: 33627664
Telomere maintenance by telomerase activation or alternative lengthening of telomeres (ALT) is a major determinant of poor outcome in neuroblastoma. Here, we screen for ALT in primary and relapsed neuroblastomas...
2.
Thole T, Toedling J, Sprussel A, Pfeil S, Savelyeva L, Capper D, et al.
Int J Cancer
. 2019 Jul;
146(4):1031-1041.
PMID: 31304977
Accurate modeling of intratumor heterogeneity presents a bottleneck against drug testing. Flexibility in a preclinical platform is also desirable to support assessment of different endpoints. We established the model system,...
3.
Zheglo D, Brueckner L, Sepman O, Wecht E, Kuligina E, Suspitsin E, et al.
Genes Chromosomes Cancer
. 2018 Nov;
58(5):284-294.
PMID: 30411419
Common fragile sites (cFSs) represent parts of the normal chromosome structure susceptible to breakage under replication stress. Although only a small number of cFSs have been molecularly characterized, genomic damage...
4.
Hasche D, Stephan S, Savelyeva L, Westermann F, Rosl F, Vinzon S
PLoS One
. 2016 Aug;
11(8):e0161283.
PMID: 27533138
In the present report we describe the establishment of a spontaneous immortalized skin keratinocyte cell line derived from the skin of the multimammate rodent Mastomys coucha. These animals are used...
5.
Peifer M, Hertwig F, Roels F, Dreidax D, Gartlgruber M, Menon R, et al.
Nature
. 2015 Oct;
526(7575):700-4.
PMID: 26466568
Neuroblastoma is a malignant paediatric tumour of the sympathetic nervous system. Roughly half of these tumours regress spontaneously or are cured by limited therapy. By contrast, high-risk neuroblastomas have an...
6.
Savelyeva L, Brueckner L
Cell Mol Life Sci
. 2014 Sep;
71(23):4561-75.
PMID: 25231336
The cytogenetic hypothesis that common fragile sites (cFSs) are hotspots of cancer breakpoints is increasingly supported by recent data from whole-genome profiles of different cancers. cFSs are components of the...
7.
Brueckner L, Hess E, Schwab M, Savelyeva L
Cancer Lett
. 2013 Apr;
336(1):85-95.
PMID: 23603433
Specific patterns of genomic aberrations have been associated with different types of malignancies. In colorectal cancer, losses of chromosome arm 8p and gains of chromosome arm 8q are among the...
8.
Gogolin S, Ehemann V, Becker G, Brueckner L, Dreidax D, Bannert S, et al.
Cell Cycle
. 2013 Mar;
12(7):1091-104.
PMID: 23462184
Relapse with drug-resistant disease is the main cause of death in MYCN-amplified neuroblastoma patients. MYCN-amplified neuroblastoma cells in vitro are characterized by a failure to arrest at the G(1)-S checkpoint...
9.
Dreidax D, Gogolin S, Schroeder C, Muth D, Brueckner L, Hess E, et al.
Hum Mol Genet
. 2013 Jan;
22(9):1735-45.
PMID: 23343716
The TP53 tumor suppressor pathway is abrogated by TP53 mutations in the majority of human cancers. Increased levels of wild-type TP53 in aggressive neuroblastomas appear paradox but are tolerated by...
10.
Milde T, Lodrini M, Savelyeva L, Korshunov A, Kool M, Brueckner L, et al.
J Neurooncol
. 2012 Oct;
110(3):335-48.
PMID: 23054560
Medulloblastomas are the most common malignant brain tumors in childhood. Emerging evidence suggests that medulloblastoma comprises at least four distinct diseases (WNT, SHH, Group 3 and 4) with different biology,...