Manfred Schwab
Overview
Explore the profile of Manfred Schwab including associated specialties, affiliations and a list of published articles.
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64
Citations
1630
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Recent Articles
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Fabian J, Opitz D, Althoff K, Lodrini M, Hero B, Volland R, et al.
Oncotarget
. 2016 Aug;
7(41):66344-66359.
PMID: 27572323
The systemic and resistant nature of metastatic neuroblastoma renders it largely incurable with current multimodal treatment. Clinical progression stems mainly from the increasing burden of metastatic colonization. Therapeutically inhibiting the...
3.
Oberthuer A, Juraeva D, Hero B, Volland R, Sterz C, Schmidt R, et al.
Clin Cancer Res
. 2014 Sep;
21(8):1904-15.
PMID: 25231397
Purpose: To optimize neuroblastoma treatment stratification, we aimed at developing a novel risk estimation system by integrating gene expression-based classification and established prognostic markers. Experimental Design: Gene expression profiles were...
4.
Asada K, Watanabe N, Nakamura Y, Ohira M, Westermann F, Schwab M, et al.
Jpn J Clin Oncol
. 2013 Apr;
43(6):641-5.
PMID: 23619990
Objective: The CpG island methylator phenotype is strongly associated with poor survival in neuroblastomas. Neuroblastomas with the CpG island methylator phenotype include almost all neuroblastomas with MYCN amplification, and, even...
5.
Brueckner L, Hess E, Schwab M, Savelyeva L
Cancer Lett
. 2013 Apr;
336(1):85-95.
PMID: 23603433
Specific patterns of genomic aberrations have been associated with different types of malignancies. In colorectal cancer, losses of chromosome arm 8p and gains of chromosome arm 8q are among the...
6.
Dreidax D, Gogolin S, Schroeder C, Muth D, Brueckner L, Hess E, et al.
Hum Mol Genet
. 2013 Jan;
22(9):1735-45.
PMID: 23343716
The TP53 tumor suppressor pathway is abrogated by TP53 mutations in the majority of human cancers. Increased levels of wild-type TP53 in aggressive neuroblastomas appear paradox but are tolerated by...
7.
Henrich K, Schwab M, Westermann F
Cancer Res
. 2012 Nov;
72(23):6079-88.
PMID: 23172308
A broad range of human malignancies is associated with nonrandom 1p36 deletions, suggesting the existence of tumor suppressors encoded in this region. Evidence for tumor-specific inactivation of 1p36 genes in...
8.
Brueckner L, Sagulenko E, Hess E, Zheglo D, Blumrich A, Schwab M, et al.
Hum Genet
. 2012 Apr;
131(8):1345-59.
PMID: 22476624
Common fragile sites (cFSs) are non-random chromosomal regions that are prone to breakage under conditions of replication stress. DNA damage and chromosomal alterations at cFSs appear to be critical events...
9.
Henderson M, Haber M, Porro A, Munoz M, Iraci N, Xue C, et al.
J Natl Cancer Inst
. 2011 Jul;
103(16):1236-51.
PMID: 21799180
Background: Although the prognostic value of the ATP-binding cassette, subfamily C (ABCC) transporters in childhood neuroblastoma is usually attributed to their role in cytotoxic drug efflux, certain observations have suggested...
10.
Henrich K, Bauer T, Schulte J, Ehemann V, Deubzer H, Gogolin S, et al.
Cancer Res
. 2011 Mar;
71(8):3142-51.
PMID: 21385898
A distal portion of human chromosome 1p is often deleted in neuroblastomas and other cancers and it is generally assumed that this region harbors one or more tumor suppressor genes....