Larissa Savelyeva
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Explore the profile of Larissa Savelyeva including associated specialties, affiliations and a list of published articles.
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28
Citations
694
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Recent Articles
11.
Brueckner L, Sagulenko E, Hess E, Zheglo D, Blumrich A, Schwab M, et al.
Hum Genet
. 2012 Apr;
131(8):1345-59.
PMID: 22476624
Common fragile sites (cFSs) are non-random chromosomal regions that are prone to breakage under conditions of replication stress. DNA damage and chromosomal alterations at cFSs appear to be critical events...
12.
Blumrich A, Zapatka M, Brueckner L, Zheglo D, Schwab M, Savelyeva L
Hum Mol Genet
. 2011 Jan;
20(8):1488-501.
PMID: 21258086
Common fragile sites (cFS) represent chromosomal regions that are prone to breakage after partial inhibition of DNA synthesis. Activation of cFS is associated with various forms of DNA instability in...
13.
Nevo I, Sagi-Assif O, Botzer L, Amar D, Maman S, Kariv N, et al.
Neoplasia
. 2008 Aug;
10(8):816-27.
PMID: 18683320
Neuroblastoma (NB) is the most commonly occurring solid tumor in children. The disease usually arises in the adrenal medulla, and it is characterized by a remarkable heterogeneity in its progression....
14.
Deubzer H, Ehemann V, Kulozik A, Westermann F, Savelyeva L, Kopp-Schneider A, et al.
Cancer Lett
. 2008 Feb;
264(1):21-8.
PMID: 18262346
Treatment of high-risk neuroblastoma (NB) is difficult. Novel therapeutics improving survival rates are urgently required. We have previously shown that the histone deacetylase inhibitor (HDACI) Helminthosporium carbonum (HC)-toxin induces differentiation...
15.
Sagulenko E, Savelyeva L, Ehemann V, Sagulenko V, Hofmann W, Arnold K, et al.
Cancer Lett
. 2007 Aug;
257(1):65-72.
PMID: 17686574
Mounting evidence implicates BRCA2 not only in maintenance of genome integrity but also in cell-cycle checkpoints. However, the contribution of BRCA2 in the checkpoints is still far from being understood....
16.
Sawinska M, Schmitt J, Sagulenko E, Westermann F, Schwab M, Savelyeva L
Genes Chromosomes Cancer
. 2007 Aug;
46(11):991-9.
PMID: 17668870
Common fragile sites represent a component of normal chromosome structure that form gaps and breaks on metaphase chromosomes after partial inhibition of DNA synthesis. In humans, cytogenetic locations of 89...
17.
Cloning of genetically tagged chromosome break sequences reveals new fragile sites at 6p21 and 13q22
Fechter A, Buettel I, Kuehnel E, Schwab M, Savelyeva L
Int J Cancer
. 2007 Feb;
120(11):2359-67.
PMID: 17290399
Fragile sites are specific genomic loci that are especially prone to chromosome breakage. For the human genome there are 31 rare fragile sites and 88 common fragile sites listed in...
18.
Fechter A, Buettel I, Kuehnel E, Savelyeva L, Schwab M
Genes Chromosomes Cancer
. 2006 Oct;
46(1):98-106.
PMID: 17063465
Fragile sites are specific genomic loci that are particularly prone to chromosomal breakage. Based on their incidence in the human population, they are divided into rare fragile sites occurring in...
19.
Hormozian F, Schmitt J, Sagulenko E, Schwab M, Savelyeva L
Cancer Lett
. 2006 Mar;
246(1-2):82-91.
PMID: 16556484
Common fragile sites represent components of normal chromosome structure that are particularly prone to breakage under replication stress. Although the cytogenetic locations of 88 common fragile sites are listed in...
20.
Arnold K, Kim M, Frerk K, Edler L, Savelyeva L, Schmezer P, et al.
Cancer Lett
. 2006 Feb;
243(1):90-100.
PMID: 16448746
The BRCA2 protein is involved in the maintenance of genomic stability through its key role in homologous recombination repair of DNA double strand breaks. Biallelic inactivation of BRCA2 leads to...