Lara Planas-Paz
Overview
Explore the profile of Lara Planas-Paz including associated specialties, affiliations and a list of published articles.
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20
Citations
599
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Recent Articles
1.
Planas-Paz L, Pauli C
Pathologie (Heidelb)
. 2024 Nov;
45(Suppl 1):14-19.
PMID: 39535612
Background: Homologous recombination deficiency (HRD) in tumors correlates with poor prognosis and metastases development. Determining HRD is of major clinical relevance as it can be treated with PARP inhibitors (PARPi)....
2.
Chen Y, Steiner S, Hagedorn C, Kollar S, Pliego-Mendieta A, Haberecker M, et al.
J Pathol
. 2024 Apr;
263(2):257-269.
PMID: 38613194
Genomic rearrangements of the neurotrophic receptor tyrosine kinase genes (NTRK1, NTRK2, and NTRK3) are the most common mechanism of oncogenic activation for this family of receptors, resulting in sustained cancer...
3.
Steiner S, Pliego-Mendieta A, Haberecker M, Hussung S, Kollar A, Fritsch R, et al.
Cancer Lett
. 2024 Jan;
584:216650.
PMID: 38246222
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis due to late detection and limited treatment options. Some PDAC patients harbor alterations that qualify for targeted treatment strategies but develop acquired...
4.
Harnisch K, Steiner S, Pliego-Mendieta A, Chen Y, Planas-Paz L, Pauli C
Hum Cell
. 2023 Nov;
37(1):356-363.
PMID: 37951844
Extraskeletal osteosarcoma (ESOS) is a rare malignant mesenchymal tumor that originates in the soft tissue. ESOS accounts for less than 1% of all soft tissue sarcomas and exhibits an aggressive...
5.
Chen Y, Herzog M, Pliego-Mendieta A, Buhler M, Harnisch K, Haberecker M, et al.
Lab Invest
. 2023 Mar;
103(4):100039.
PMID: 36870294
Responses to therapy often cannot be exclusively predicted by molecular markers, thus evidencing a critical need to develop tools for better patient selection based on relations between tumor phenotype and...
6.
Planas-Paz L, Pliego-Mendieta A, Hagedorn C, Aguilera-Garcia D, Haberecker M, Arnold F, et al.
EMBO Mol Med
. 2023 Feb;
15(4):e16863.
PMID: 36779660
Defects in homologous recombination repair (HRR) in tumors correlate with poor prognosis and metastases development. Determining HRR deficiency (HRD) is of major clinical relevance as it is associated with therapeutic...
7.
Bangerter J, Harnisch K, Chen Y, Hagedorn C, Planas-Paz L, Pauli C
Hum Cell
. 2022 Nov;
36(1):446-455.
PMID: 36316541
Extraskeletal myxoid chondrosarcoma (EMC) is a malignant mesenchymal neoplasm of uncertain differentiation as classified by the WHO Classification of Tumours 2020. Although often associated with pronlonged survival, EMC has high...
8.
Paul A, Annunziato S, Lu B, Sun T, Evrova O, Planas-Paz L, et al.
Nat Commun
. 2022 Feb;
13(1):930.
PMID: 35177623
The Hippo/YAP pathway controls cell proliferation through sensing physical and spatial organization of cells. How cell-cell contact is sensed by Hippo signaling is poorly understood. Here, we identified the cell...
9.
Pauli C, De Boni L, Pauwels J, Chen Y, Planas-Paz L, Shaw R, et al.
Mol Cancer Res
. 2021 Nov;
20(2):244-252.
PMID: 34728552
In this era of precision medicine, numerous workflows for the targeting of high-recurrent mutations in common tumor types have been developed, leaving patients with rare diseases with few options. Here,...
10.
Sun T, Pikiolek M, Orsini V, Bergling S, Holwerda S, Morelli L, et al.
Cell Stem Cell
. 2019 Dec;
26(1):97-107.e6.
PMID: 31866224
The existence of specialized liver stem cell populations, including AXIN2 pericentral hepatocytes, that safeguard homeostasis and repair has been controversial. Here, using AXIN2 lineage tracing in BAC-transgenic mice, we confirm...