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L Keith Henry

Explore the profile of L Keith Henry including associated specialties, affiliations and a list of published articles. Areas
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Articles 26
Citations 635
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Recent Articles
1.
Vaughan R, Henry L, Foster J, Brown C
Adv Pharmacol . 2024 Mar; 99:1-33. PMID: 38467478
The availability of monoamine neurotransmitters in the brain is under the control of dopamine, norepinephrine, and serotonin transporters expressed on the plasma membrane of monoaminergic neurons. By regulating transmitter levels...
2.
Ansar M, Ranza E, Shetty M, Paracha S, Azam M, Kern I, et al.
Hum Mol Genet . 2020 Jan; 29(4):618-623. PMID: 31903486
In a consanguineous Pakistani family with two affected individuals, a homozygous variant Gly399Val in the eighth transmembrane domain of the taurine transporter SLC6A6 was identified resulting in a hypomorph transporting...
3.
Quinlan M, Krout D, Katamish R, Robson M, Nettesheim C, Gresch P, et al.
ACS Chem Neurosci . 2019 Jan; 10(7):3249-3260. PMID: 30668912
The antidepressant-sensitive serotonin (5-HT) transporter (SERT) dictates rapid, high-affinity clearance of the neurotransmitter in both the brain and periphery. In a study of families with multiple individuals diagnosed with autism...
4.
Tomlinson M, Krout D, Pramod A, Lever J, Newman A, Henry L, et al.
Neurochem Int . 2018 Aug; 123:34-45. PMID: 30125594
The dopamine transporter (DAT) is a neuronal membrane protein that is responsible for reuptake of dopamine (DA) from the synapse and functions as a major determinant in control of DA...
5.
Sambo D, Lin M, Owens A, Lebowitz J, Richardson B, Jagnarine D, et al.
Nat Commun . 2017 Dec; 8(1):2228. PMID: 29263318
Dopamine neurotransmission is highly dysregulated by the psychostimulant methamphetamine, a substrate for the dopamine transporter (DAT). Through interactions with DAT, methamphetamine increases extracellular dopamine levels in the brain, leading to...
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Krout D, Pramod A, Dahal R, Tomlinson M, Sharma B, Foster J, et al.
Biochem Pharmacol . 2017 Jul; 142:204-215. PMID: 28734777
Dopamine transporter (DAT) blockers like cocaine and many other abused and therapeutic drugs bind and stabilize an inactive form of the transporter inhibiting reuptake of extracellular dopamine (DA). The resulting...
8.
Simmler L, Anacker A, Levin M, Vaswani N, Gresch P, Nackenoff A, et al.
Br J Pharmacol . 2017 Jun; 174(16):2716-2738. PMID: 28585320
Background And Purpose: The psychostimulant cocaine induces complex molecular, cellular and behavioural responses as a consequence of inhibiting presynaptic dopamine, noradrenaline and 5-HT transporters. To elucidate 5-HT transporter (SERT)-specific contributions...
9.
Krout D, Rodriquez M, Brose S, Golovko M, Henry L, Thompson B
ACS Chem Neurosci . 2016 Dec; 8(5):1011-1018. PMID: 27959497
Previous studies of transgenic mice carrying a single isoleucine to methionine substitution (I172M) in the serotonin transporter (SERT) demonstrated a loss of sensitivity to multiple antidepressants (ADs) at SERT. However,...
10.
Sealover N, Felts B, Kuntz C, Jarrard R, Hockerman G, Lamb P, et al.
Biochem Pharmacol . 2016 Sep; 120:46-55. PMID: 27638414
The substituted amphetamine, 3,4-methylenedioxy-methamphetamine (MDMA, ecstasy), is a widely used drug of abuse that induces non-exocytotic release of serotonin, dopamine, and norepinephrine through their cognate transporters as well as blocking...