Madhur Shetty
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Explore the profile of Madhur Shetty including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
167
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Recent Articles
1.
Brown C, Shetty M, Foster J
J Neurochem
. 2024 Oct;
169(2):e16241.
PMID: 39395208
Postural orthostatic tachycardia syndrome (POTS) is an adrenergic signaling disorder characterized by excessive plasma norepinephrine, postural tachycardia, and syncope. The norepinephrine transporter (NET) modulates adrenergic homeostasis via the reuptake of...
2.
Nanaware P, Khan Z, Clement C, Shetty M, Mota I, Seltzer E, et al.
Cell Rep
. 2024 Jun;
43(6):114311.
PMID: 38848214
The lymphatic fluid is the conduit by which part of the tissue "omics" is transported to the draining lymph node for immunosurveillance. Following cannulation of the pre-nodal cervical and mesenteric...
3.
Shetty M, Bolland D, Morrell J, Grove B, Foster J, Vaughan R
Curr Res Physiol
. 2023 Dec;
6:100106.
PMID: 38107792
The primary regulator of dopamine availability in the brain is the dopamine transporter (DAT), a plasma membrane protein that drives reuptake of released dopamine from the extracellular space into the...
4.
Clement C, Osan J, Buque A, Nanaware P, Chang Y, Perino G, et al.
Sci Immunol
. 2022 Aug;
7(74):eabl3795.
PMID: 35984892
A diet rich in saturated fat and carbohydrates causes low-grade chronic inflammation in several organs, including the liver, ultimately driving nonalcoholic steatohepatitis. In this setting, environment-driven lipotoxicity and glucotoxicity induce...
5.
Ansar M, Ranza E, Shetty M, Paracha S, Azam M, Kern I, et al.
Hum Mol Genet
. 2020 Jan;
29(4):618-623.
PMID: 31903486
In a consanguineous Pakistani family with two affected individuals, a homozygous variant Gly399Val in the eighth transmembrane domain of the taurine transporter SLC6A6 was identified resulting in a hypomorph transporting...
6.
Yang J, Larson G, Konrad L, Shetty M, Holy M, Jantsch K, et al.
J Biol Chem
. 2018 Dec;
294(10):3419-3431.
PMID: 30587577
Several protein kinases, including protein kinase C, Ca/calmodulin-dependent protein kinase II, and extracellular signal-regulated kinase, play key roles in the regulation of dopamine transporter (DAT) functions. These functions include surface...
7.
Sambo D, Lin M, Owens A, Lebowitz J, Richardson B, Jagnarine D, et al.
Nat Commun
. 2017 Dec;
8(1):2228.
PMID: 29263318
Dopamine neurotransmission is highly dysregulated by the psychostimulant methamphetamine, a substrate for the dopamine transporter (DAT). Through interactions with DAT, methamphetamine increases extracellular dopamine levels in the brain, leading to...
8.
Chandrani P, Upadhyay P, Iyer P, Tanna M, Shetty M, Raghuram G, et al.
BMC Genomics
. 2015 Nov;
16:936.
PMID: 26572163
Background: Several statistical tools have been developed to identify genes mutated at rates significantly higher than background, indicative of positive selection, involving large sample cohort studies. However, studies involving smaller...
9.
Moritz A, Rastedt D, Stanislowski D, Shetty M, Smith M, Vaughan R, et al.
J Biol Chem
. 2015 Oct;
290(48):29095-105.
PMID: 26424792
The dopamine transporter is a neuronal protein that drives the presynaptic reuptake of dopamine (DA) and is the major determinant of transmitter availability in the brain. Dopamine transporter function is...
10.
Gaffaney J, Shetty M, Felts B, Pramod A, Foster J, Henry L, et al.
Neurochem Int
. 2013 Nov;
73:16-26.
PMID: 24269640
Ligand-induced changes in the conformation of extracellular loop (EL) 2 in the rat (r) dopamine transporter (DAT) were examined using limited proteolysis with endoproteinase Asp-N and detection of cleavage products...