Roxanne A Vaughan
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Explore the profile of Roxanne A Vaughan including associated specialties, affiliations and a list of published articles.
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45
Citations
1253
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Recent Articles
1.
Vaughan R, Henry L, Foster J, Brown C
Adv Pharmacol
. 2024 Mar;
99:1-33.
PMID: 38467478
The availability of monoamine neurotransmitters in the brain is under the control of dopamine, norepinephrine, and serotonin transporters expressed on the plasma membrane of monoaminergic neurons. By regulating transmitter levels...
2.
Shetty M, Bolland D, Morrell J, Grove B, Foster J, Vaughan R
Curr Res Physiol
. 2023 Dec;
6:100106.
PMID: 38107792
The primary regulator of dopamine availability in the brain is the dopamine transporter (DAT), a plasma membrane protein that drives reuptake of released dopamine from the extracellular space into the...
3.
Mayer F, Stewart A, Varman D, Moritz A, Foster J, Owens A, et al.
bioRxiv
. 2023 May;
PMID: 37205452
Aberrant dopamine (DA) signaling is implicated in schizophrenia, bipolar disorder (BPD), autism spectrum disorder (ASD), substance use disorder, and attention-deficit/hyperactivity disorder (ADHD). Treatment of these disorders remains inadequate, as exemplified...
4.
Stewart A, Mayer F, Gowrishankar R, Davis G, Areal L, Gresch P, et al.
Mol Psychiatry
. 2022 Sep;
27(12):4869-4880.
PMID: 36117213
Virtually all neuropsychiatric disorders display sex differences in prevalence, age of onset, and/or clinical symptomology. Although altered dopamine (DA) signaling is a feature of many of these disorders, sex-dependent mechanisms...
5.
Hovde M, Bolland D, Armand A, Pitsch E, Bakker C, Kooiker A, et al.
Life Sci
. 2021 Nov;
288:120142.
PMID: 34774621
Aims: Determine the effect of palmitoylation on the sodium hydrogen exchanger isoform 1 (NHE1), a member of the SLC9 family. Main Methods: NHE1 expressed in native rat tissues or in...
6.
De Deurwaerdere P, Gaetani S, Vaughan R
J Neurochem
. 2020 Jan;
152(6):623-626.
PMID: 31917872
The dorsal striatum coordinates input-output processing of numerous functions including those related to motor activity, motivation, and learning. Considerable anatomical and biochemical heterogeneity across striatal subregions has long been known...
7.
Bolland D, Moritz A, Stanislowski D, Vaughan R, Foster J
ACS Chem Neurosci
. 2019 Apr;
10(6):2707-2717.
PMID: 30965003
The dopamine transporter (DAT) is a plasma membrane protein that mediates the reuptake of extracellular dopamine (DA) and controls the spatiotemporal dynamics of dopaminergic neurotransmission. The transporter is subject to...
8.
Yang J, Larson G, Konrad L, Shetty M, Holy M, Jantsch K, et al.
J Biol Chem
. 2018 Dec;
294(10):3419-3431.
PMID: 30587577
Several protein kinases, including protein kinase C, Ca/calmodulin-dependent protein kinase II, and extracellular signal-regulated kinase, play key roles in the regulation of dopamine transporter (DAT) functions. These functions include surface...
9.
Hovde M, Larson G, Vaughan R, Foster J
Neurochem Int
. 2018 Sep;
123:13-21.
PMID: 30179648
The dopamine transporter (DAT) plays a critical role in dopamine (DA) homeostasis by clearing transmitter from the extraneuronal space after vesicular release. DAT serves as a site of action for...
10.
Tomlinson M, Krout D, Pramod A, Lever J, Newman A, Henry L, et al.
Neurochem Int
. 2018 Aug;
123:34-45.
PMID: 30125594
The dopamine transporter (DAT) is a neuronal membrane protein that is responsible for reuptake of dopamine (DA) from the synapse and functions as a major determinant in control of DA...