L Darryl Quarles
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Explore the profile of L Darryl Quarles including associated specialties, affiliations and a list of published articles.
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126
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6111
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Recent Articles
1.
Joshi A, Xiao Z, Suman S, Cooper C, Ha K, Agarwal R, et al.
bioRxiv
. 2025 Jan;
PMID: 39763828
Human Interleukin-6 (hIL-6) is a pro inflammatory cytokine that binds to its receptor, IL-6Rα followed by binding to gp130 and subsequent dimerization to form a hexamer signaling complex. A critical...
2.
Osteocalcin binds to a GPRC6A Venus fly trap allosteric site to positively modulate GPRC6A signaling
Agarwal R, Ye R, Smith M, Smith J, Quarles L, Pi M
FASEB Bioadv
. 2024 Oct;
6(9):365-376.
PMID: 39399472
GPRC6A, a member of the Family C G-protein coupled receptors, regulates energy metabolism and sex hormone production and is activated by diverse ligands, including cations, L-amino acids, the osteocalcin (Ocn)...
3.
Pi M, Agarwal R, Smith M, Smith J, Quarles L
bioRxiv
. 2024 Sep;
PMID: 39229180
Understanding the mechanism of metformin actions in treating type 2 diabetes is limited by an incomplete knowledge of the specific protein targets mediating its metabolic effects. Metformin has structural similarities...
4.
Huang M, Zhou J, Li X, Liu R, Jiang Y, Chen K, et al.
Sci Bull (Beijing)
. 2024 May;
69(12):1964-1979.
PMID: 38760248
Mechanical loading is required for bone homeostasis, but the underlying mechanism is still unclear. Our previous studies revealed that the mechanical protein polycystin-1 (PC1, encoded by Pkd1) is critical for...
5.
Liu R, Jiao Y, Huang M, Zou N, He C, Huang M, et al.
Theranostics
. 2024 Apr;
14(6):2544-2559.
PMID: 38646641
Mechanical forces are indispensable for bone healing, disruption of which is recognized as a contributing cause to nonunion or delayed union. However, the underlying mechanism of mechanical regulation of fracture...
6.
Smith M, Quarles L, Demerdash O, Smith J
Drug Discov Today
. 2024 Jan;
29(3):103891.
PMID: 38246414
Each of the ∼20,000 proteins in the human proteome is a potential target for compounds that bind to it and modify its function. The 3D structures of most of these...
7.
Liu S, Xiao Z, Smith J, Quarles L
Trends Pharmacol Sci
. 2023 Oct;
44(12):862-864.
PMID: 37778940
Chen et al. have derived cryogenic electron microscopy (cryo-EM) structures of signaling complexes of the endocrine hormone fibroblast growth factor 23 (FGF23) with fibroblast growth factor receptor (FGFR), α-Klotho, and...
8.
Liu S, Xiao Z, Mishra S, Mitchell J, Smith J, Quarles L, et al.
J Chem Inf Model
. 2022 Jul;
62(15):3627-3637.
PMID: 35868851
Fibroblast growth factor 23 (FGF23) is a therapeutic target for treating hereditary and acquired hypophosphatemic disorders, such as X-linked hypophosphatemic (XLH) rickets and tumor-induced osteomalacia (TIO), respectively. FGF23-induced hypophosphatemia is...
9.
Kovesdy C, Adebiyi A, Rosenbaum D, Jacobs J, Quarles L
Int J Nephrol Renovasc Dis
. 2021 Dec;
14:411-420.
PMID: 34880650
Plasma membrane sodium-hydrogen exchangers (NHE) transport Na into cells in exchange for H. While there are nine isoforms of NHE in humans, this review focuses on the NHE3 isoform, which...
10.
Pi M, Nishimoto S, Quarles L
Endocrinology
. 2021 Jan;
162(4).
PMID: 33474566
A new schema proposes that the bone-derived osteocalcin (Ocn) peptide hormone activates the G-protein-coupled receptor GPRC6A to directly regulate glucose and fat metabolism in liver, muscle, and fat, and to...