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Min Pi

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Articles 45
Citations 1472
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Recent Articles
1.
Agarwal R, Ye R, Smith M, Smith J, Quarles L, Pi M
FASEB Bioadv . 2024 Oct; 6(9):365-376. PMID: 39399472
GPRC6A, a member of the Family C G-protein coupled receptors, regulates energy metabolism and sex hormone production and is activated by diverse ligands, including cations, L-amino acids, the osteocalcin (Ocn)...
2.
Pi M, Agarwal R, Smith M, Smith J, Quarles L
bioRxiv . 2024 Sep; PMID: 39229180
Understanding the mechanism of metformin actions in treating type 2 diabetes is limited by an incomplete knowledge of the specific protein targets mediating its metabolic effects. Metformin has structural similarities...
3.
Zhang Q, Halle J, Counts B, Pi M, Carson J
Am J Physiol Cell Physiol . 2024 May; 327(1):C124-C139. PMID: 38766767
Protein synthesis regulation is critical for skeletal muscle hypertrophy, yet other established cellular processes are necessary for growth-related cellular remodeling. Autophagy has a well-acknowledged role in muscle quality control, but...
4.
Wang Y, Zhang R, Pi M, Xu J, Qiu M, Wen T
Evid Based Complement Alternat Med . 2021 Nov; 2021:6095476. PMID: 34845412
Objective: To predict the major comorbidities of type 2 diabetes based on the distribution characteristics of syndromes, and to explore the relationship between TCM syndromes and comorbidities of type 2...
5.
Xing Y, Pi M, Zhang R, Wen T
Evid Based Complement Alternat Med . 2021 Jul; 2021:1282957. PMID: 34221067
Objective: The purpose of this study is to analyze and summarize the syndrome distribution, syndrome evolution, and Chinese herb medicine characteristics of T2D in heat stage. Method: In this study,...
6.
Pi M, Nishimoto S, Quarles L
Endocrinology . 2021 Jan; 162(4). PMID: 33474566
A new schema proposes that the bone-derived osteocalcin (Ocn) peptide hormone activates the G-protein-coupled receptor GPRC6A to directly regulate glucose and fat metabolism in liver, muscle, and fat, and to...
7.
Kapoor K, Pi M, Nishimoto S, Quarles L, Baudry J, Smith J
Biochim Biophys Acta Gen Subj . 2020 Dec; 1865(3):129809. PMID: 33340588
Background: The carboxylation status of Osteocalcin (Ocn) not only influences formation and structure in bones but also has important endocrine functions affecting energy metabolism and expenditure. In this study, the...
8.
Pi M, Xu F, Ye R, Nishimoto S, Kesterson R, Williams R, et al.
Sci Rep . 2020 Jul; 10(1):11143. PMID: 32636482
GPRC6A is proposed to regulate energy metabolism in mice, but in humans a KGKY polymorphism in the third intracellular loop (ICL3) is proposed to result in intracellular retention and loss-of-function....
9.
Pi M, Xu F, Ye R, Nishimoto S, Williams R, Lu L, et al.
Sci Rep . 2020 May; 10(1):7216. PMID: 32350388
GPRC6A is a widely expressed G-protein coupled receptor that regulates energy metabolism. Global deletion of Gprc6a in mice is reported to result in a metabolic syndrome-like phenotype and conditional deletion...
10.
Ye R, Pi M, Nooh M, Bahout S, Quarles L
Mol Pharmacol . 2019 Mar; 95(5):563-572. PMID: 30894404
G protein-coupled receptor family C group 6 member A (GPRC6A) is activated by testosterone and modulates prostate cancer progression. Most humans have a GPRC6A variant that contains a recently evolved...