Kyle A Rasbach
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Explore the profile of Kyle A Rasbach including associated specialties, affiliations and a list of published articles.
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11
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2903
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Recent Articles
1.
Jesinkey S, Korrapati M, Rasbach K, Beeson C, Schnellmann R
J Pharmacol Exp Ther
. 2014 Oct;
351(3):663-73.
PMID: 25292181
Skeletal muscle atrophy remains a clinical problem in numerous pathologic conditions. β2-Adrenergic receptor agonists, such as formoterol, can induce mitochondrial biogenesis (MB) to prevent such atrophy. Additionally, atomoxetine, an FDA-approved...
2.
Ruas J, White J, Rao R, Kleiner S, Brannan K, Harrison B, et al.
Cell
. 2012 Dec;
151(6):1319-31.
PMID: 23217713
PGC-1α is a transcriptional coactivator induced by exercise that gives muscle many of the best known adaptations to endurance-type exercise but has no effects on muscle strength or hypertrophy. We...
3.
Bostrom P, Wu J, Jedrychowski M, Korde A, Ye L, Lo J, et al.
Nature
. 2012 Jan;
481(7382):463-8.
PMID: 22237023
Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here...
4.
Wu J, Ruas J, Estall J, Rasbach K, Choi J, Ye L, et al.
Cell Metab
. 2011 Feb;
13(2):160-9.
PMID: 21284983
Exercise has been shown to be effective for treating obesity and type 2 diabetes. However, the molecular mechanisms for adaptation to exercise training are not fully understood. Endoplasmic reticulum (ER)...
5.
Rasbach K, Gupta R, Ruas J, Wu J, Naseri E, Estall J, et al.
Proc Natl Acad Sci U S A
. 2010 Nov;
107(50):21866-71.
PMID: 21106753
The coactivator peroxisome proliferator-activated receptor-gamma coactivator 1 α (PGC-1α) coordinates a broad set of transcriptional programs that regulate the response of skeletal muscle to exercise. However, the complete transcriptional network...
6.
Rasbach K, Funk J, Jayavelu T, Green P, Schnellmann R
J Pharmacol Exp Ther
. 2009 Oct;
332(2):632-9.
PMID: 19875674
Mitochondrial dysfunction is both a cause and target of reactive oxygen species during ischemia-reperfusion, drug, and toxicant injury. After injury, renal proximal tubular cells (RPTC) recover mitochondrial function by increasing...
7.
Rasbach K, Arrington D, Odejinmi S, Giguere C, Beeson C, Schnellmann R
J Med Chem
. 2008 Dec;
52(1):181-8.
PMID: 19072163
Calpain 10 has been localized to the mitochondria and is a key mediator of Ca(2+) induced mitochondrial dysfunction. A peptide screen followed by a series of modifications identified the homodisulfide...
8.
Rasbach K, Green P, Schnellmann R
Arch Biochem Biophys
. 2008 Aug;
478(2):130-5.
PMID: 18718443
Peroxisome proliferator activator receptor gamma coactivator 1alpha (PGC-1alpha) is a transcriptional coactivator known to mediate mitochondrial biogenesis. Whereas PGC-1alpha transcription is regulated by a variety of signaling cascades, the mechanisms...
9.
Rasbach K, Schnellmann R
J Pharmacol Exp Ther
. 2008 Feb;
325(2):536-43.
PMID: 18267976
Mitochondrial damage is often both the cause and outcome of cell injury resulting from a variety of toxic insults, hypoxia, or trauma. Increasing mitochondrial biogenesis after renal proximal tubular cell...
10.
Rasbach K, Schnellmann R
Biochem Biophys Res Commun
. 2007 Feb;
355(3):734-9.
PMID: 17307137
Cell death from mitochondrial dysfunction and compromised bioenergetics is common after ischemia-reperfusion injury and toxicant exposure. Thus, promoting mitochondrial biogenesis is therapeutically attractive for sustaining oxidative phosphorylation and maintaining ATP-dependent...