A PGC1-α-dependent Myokine That Drives Brown-fat-like Development of White Fat and Thermogenesis

Overview

Journal Nature

Specialty Science

Date 2012 Jan 13

PMID 22237023

Citations 2048

Authors

Pontus Bostrom

Jun Wu

Mark P Jedrychowski

Anisha Korde

Li Ye

James C Lo

Kyle A Rasbach

Elisabeth Almer Bostrom

Jang Hyun Choi

Jonathan Z Long

Shingo Kajimura

Maria Cristina Zingaretti

Birgitte F Vind

Hua Tu

Saverio Cinti

Kurt Hojlund

Steven P Gygi

Bruce M Spiegelman

Affiliations

Soon will be listed here.

Abstract

Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we show in mouse that PGC1-α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin. Irisin acts on white adipose cells in culture and in vivo to stimulate UCP1 expression and a broad program of brown-fat-like development. Irisin is induced with exercise in mice and humans, and mildly increased irisin levels in the blood cause an increase in energy expenditure in mice with no changes in movement or food intake. This results in improvements in obesity and glucose homeostasis. Irisin could be therapeutic for human metabolic disease and other disorders that are improved with exercise.

Citing Articles

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