Kurt Januszyk
Overview
Explore the profile of Kurt Januszyk including associated specialties, affiliations and a list of published articles.
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15
Citations
705
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Recent Articles
1.
Pleiner T, Hazu M, Pinton Tomaleri G, Nguyen V, Januszyk K, Voorhees R
J Cell Biol
. 2023 May;
222(8).
PMID: 37199759
Tail-anchored (TA) proteins play essential roles in mammalian cells, and their accurate localization is critical for proteostasis. Biophysical similarities lead to mistargeting of mitochondrial TA proteins to the ER, where...
2.
Pleiner T, Hazu M, Pinton Tomaleri G, Januszyk K, Oania R, Sweredoski M, et al.
Mol Cell
. 2021 May;
81(13):2693-2704.e12.
PMID: 33964204
The assembly of nascent proteins into multi-subunit complexes is a tightly regulated process that must occur at high fidelity to maintain cellular homeostasis. The ER membrane protein complex (EMC) is...
3.
Pleiner T, Pinton Tomaleri G, Januszyk K, Inglis A, Hazu M, Voorhees R
Science
. 2020 May;
369(6502):433-436.
PMID: 32439656
A defining step in the biogenesis of a membrane protein is the insertion of its hydrophobic transmembrane helices into the lipid bilayer. The nine-subunit endoplasmic reticulum (ER) membrane protein complex...
4.
Januszyk K, Weick E, Lima C
Methods Mol Biol
. 2019 Nov;
2062:467-489.
PMID: 31768991
We describe procedures to clone, express, and reconstitute an active human nuclear RNA exosome. Individual recombinant subunits are expressed from E. coli and successfully reconstituted into the nuclear complex, which...
5.
Januszyk K, Lima C
Methods Mol Biol
. 2019 Nov;
2062:449-465.
PMID: 31768990
In this chapter, we describe methods to clone, express, purify, and reconstitute active S. pombe RNA exosomes. Reconstitution procedures are similar to methods that have been successful for the human...
6.
Weick E, Puno M, Januszyk K, Zinder J, DiMattia M, Lima C
Cell
. 2018 Jun;
173(7):1663-1677.e21.
PMID: 29906447
The ribonucleolytic RNA exosome interacts with RNA helicases to degrade RNA. To understand how the 3' to 5' Mtr4 helicase engages RNA and the nuclear exosome, we reconstituted 14-subunit Mtr4-containing...
7.
Wasmuth E, Januszyk K, Lima C
Nature
. 2014 Jul;
511(7510):435-9.
PMID: 25043052
The eukaryotic RNA exosome processes and degrades RNA by directing substrates to the distributive or processive 3' to 5' exoribonuclease activities of Rrp6 or Rrp44, respectively. The non-catalytic nine-subunit exosome...
8.
Januszyk K, Lima C
Curr Opin Struct Biol
. 2014 Feb;
24:132-40.
PMID: 24525139
The eukaryotic RNA exosome is an essential multi-subunit ribonuclease complex that contributes to the degradation or processing of nearly every class of RNA in both the nucleus and cytoplasm. Its...
9.
Januszyk K, Lima C
Adv Exp Med Biol
. 2011 Jun;
702:9-28.
PMID: 21713674
A large body of structural work conducted over the past ten years has elucidated mechanistic details related to 3' to 5' processing and decay of RNA substrates by the RNA...
10.
Januszyk K, Liu Q, Lima C
RNA
. 2011 Jun;
17(8):1566-77.
PMID: 21705430
The eukaryotic RNA exosome is a highly conserved multi-subunit complex that catalyzes degradation and processing of coding and noncoding RNA. A noncatalytic nine-subunit exosome core interacts with Rrp44 and Rrp6,...