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» Authors » Kumaraguruparan Ramasamy

Kumaraguruparan Ramasamy

Explore the profile of Kumaraguruparan Ramasamy including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 14
Citations 501
Followers 0
Related Specialties
Oncology
Microbiology
Molecular Biology
Top 10 Co-Authors
Joel B Baseman
Rajesh Agarwal
Lavanya Pandranki
Rana P Singh
T R Kannan
Rajeshwar R Tekmal
Sowmya Balasubramanian
Komal Raina
Hareesh B Nair
Alpna Tyagi
Published In
mBio
Cancer Lett
Clin Cancer Res
Mol Microbiol
Cell Microbiol
Affiliations
Soon will be listed here.
Recent Articles
1.
Inhibition of LIFR Blocks Adiposity-Driven Endometrioid Endometrial Cancer Growth
Blankenship L, Pratap U, Yang X, Liu Z, Altwegg K, Santhamma B, et al.
Cancers (Basel) . 2022 Nov; 14(21). PMID: 36358818
Endometrial cancer (EC) is the fourth most common cancer in women, and half of the endometrioid EC (EEC) cases are attributable to obesity. However, the underlying mechanism(s) of obesity-driven EEC...
2.
LIF/LIFR oncogenic signaling is a novel therapeutic target in endometrial cancer
Tang W, Ramasamy K, Pillai S, Santhamma B, Konda S, Pitta Venkata P, et al.
Cell Death Discov . 2021 Aug; 7(1):216. PMID: 34400617
Endometrial cancer (EC) is the fourth most common cancer in women. Advanced-stage EC has limited treatment options with a poor prognosis. There is an unmet need for the identification of...
3.
Mycoplasma pneumoniae CARDS toxin exploits host cell endosomal acidic pH and vacuolar ATPase proton pump to execute its biological activities
Ramasamy K, Balasubramanian S, Kirkpatrick A, Szabo D, Pandranki L, Baseman J, et al.
Sci Rep . 2021 Jun; 11(1):11571. PMID: 34078958
Mycoplasma pneumoniae is the leading cause of bacterial community-acquired pneumonia among hospitalized children in the United States. It is also responsible for a spectrum of other respiratory tract disorders and ...
4.
Disulfide bond of Mycoplasma pneumoniae community-acquired respiratory distress syndrome toxin is essential to maintain the ADP-ribosylating and vacuolating activities
Balasubramanian S, Pandranki L, Maupin S, Ramasamy K, Taylor A, Hart P, et al.
Cell Microbiol . 2019 Apr; 21(8):e13032. PMID: 30977272
Mycoplasma pneumoniae is the leading cause of bacterial community-acquired pneumonia among hospitalised children in United States and worldwide. Community-acquired respiratory distress syndrome (CARDS) toxin is a key virulence determinant of...
5.
Community-Acquired Respiratory Distress Syndrome Toxin Uses a Novel KELED Sequence for Retrograde Transport and Subsequent Cytotoxicity
Ramasamy K, Balasubramanian S, Manickam K, Pandranki L, Taylor A, Hart P, et al.
mBio . 2018 Jan; 9(1). PMID: 29362229
is an atypical bacterium that causes respiratory illnesses in humans, including pharyngitis, tracheobronchitis, and community-acquired pneumonia (CAP). It has also been directly linked to reactive airway disease, asthma, and extrapulmonary...
6.
Therapeutic Use of Estrogen Receptor β Agonists in Prevention and Treatment of Endocrine Therapy Resistant Breast Cancers: Observations From Preclinical Models
Ramasamy K, Samayoa C, Krishnegowda N, Tekmal R
Prog Mol Biol Transl Sci . 2017 Nov; 151:177-194. PMID: 29096893
Breast cancer is one of the most common cancers in the world. The majority of breast cancers express estrogen receptor (ER)α, and endocrine therapy is the primary therapeutic approach to...
7.
Annexin A2 mediates Mycoplasma pneumoniae community-acquired respiratory distress syndrome toxin binding to eukaryotic cells
Somarajan S, Al-Asadi F, Ramasamy K, Pandranki L, Baseman J, Kannan T
mBio . 2014 Aug; 5(4). PMID: 25139904
Unlabelled: Mycoplasma pneumoniae synthesizes a novel human surfactant protein A (SP-A)-binding cytotoxin, designated community-acquired respiratory distress syndrome (CARDS) toxin, that exhibits ADP-ribosylating and vacuolating activities in mammalian cells and is...
8.
Functional mapping of community-acquired respiratory distress syndrome (CARDS) toxin of Mycoplasma pneumoniae defines regions with ADP-ribosyltransferase, vacuolating and receptor-binding activities
Kannan T, Krishnan M, Ramasamy K, Becker A, Pakhomova O, Hart P, et al.
Mol Microbiol . 2014 Jun; 93(3):568-81. PMID: 24948331
Community-acquired respiratory distress syndrome (CARDS) toxin from Mycoplasma pneumoniae is a 591-amino-acid virulence factor with ADP-ribosyltransferase (ADPRT) and vacuolating activities. It is expressed at low levels during in vitro growth...
9.
Poly[3-(3, 4-dihydroxyphenyl) glyceric acid] from Comfrey exerts anti-cancer efficacy against human prostate cancer via targeting androgen receptor, cell cycle arrest and apoptosis
Shrotriya S, Gagan D, Ramasamy K, Raina K, Barbakadze V, Merlani M, et al.
Carcinogenesis . 2012 Jun; 33(8):1572-80. PMID: 22693258
The major obstacles in human prostate cancer (PCA) treatment are the development of resistance to androgen ablation therapy leading to hormone-refractory state and the toxicity associated with chemotherapeutic drugs. Thus,...
10.
MicroRNAs miR-125a and miR-125b constitutively activate the NF-κB pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20)
Kim S, Ramasamy K, Bouamar H, Lin A, Jiang D, Aguiar R
Proc Natl Acad Sci U S A . 2012 May; 109(20):7865-70. PMID: 22550173
Constitutive activation of the NF-κB pathway is associated with diffuse large B-cell lymphoma (DLBCL) pathogenesis, but whether microRNA dysfunction can contribute to these events remains unclear. Starting from an integrative...