Kuang Yu Chen
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Explore the profile of Kuang Yu Chen including associated specialties, affiliations and a list of published articles.
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23
Citations
407
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Recent Articles
1.
Liu A, Mathew A, Karim C, Eshak P, Chen K
Prog Mol Biol Transl Sci
. 2025 Feb;
211:113-143.
PMID: 39947746
Huntington Disease is an autosomal dominant neurodegenerative disease caused by expansion of the polymorphic trinucleotide CAG repeat of the HTT gene to code for an expanded glutamine track of the...
2.
Castro E Costa A, Mysore S, Paruchuri P, Chen K, Liu A
ACS Chem Neurosci
. 2022 Dec;
14(2):277-288.
PMID: 36574489
Age-dependent formation of insoluble protein aggregates is a hallmark of many neurodegenerative diseases. We are interested in the cell chemistry that drives the aggregation of polyQ-expanded mutant Huntingtin (mHtt) protein...
3.
Liu A, Minetti C, Remeta D, Breslauer K, Chen K
Adv Exp Med Biol
. 2022 Aug;
1409:23-49.
PMID: 35995906
Objectives: Herein we discuss the regulation and function of HSF1 as they relate to the pathophysiological changes of protein quality control in aging and neurodegenerative diseases (ND). Methods: We present...
4.
Aravindan S, Chen S, Choudhry H, Molfetta C, Chen K, Liu A
Sci Rep
. 2020 Sep;
10(1):15511.
PMID: 32968182
Osmolytes are organic solutes that change the protein folding landscape shifting the equilibrium towards the folded state. Herein, we use osmolytes to probe the structuring and aggregation of the intrinsically...
5.
Chen J, Parekh M, Seliman H, Bakshinskaya D, Dai W, Kwan K, et al.
J Biol Chem
. 2018 Aug;
293(40):15581-15593.
PMID: 30143534
PolyQ-expanded huntingtin (mHtt) variants form aggregates, termed inclusion bodies (IBs), in individuals with and models of Huntington's disease (HD). The role of IB diffusible mHtt in neurotoxicity remains unclear. Using...
6.
Verma R, Chen K
Front Biosci
. 2017 May;
2:a26-30.
PMID: 28481202
Nuclear kinase II (nuclear casein kinase 2) is a multifunctional, second messenger-independent protein serine/threonine kinase that phosphorylates many different nuclear proteins, including high mobility group (HMG) proteins, heterogeneous nuclear ribonuleoprotein...
7.
Liu D, Hammer D, Komlos D, Chen K, Firestein B, Liu A
J Cell Physiol
. 2014 Jan;
229(9):1224-35.
PMID: 24435709
Neurons have a limited capacity for heat shock protein (HSP) induction and are vulnerable to the pathogenic consequence of protein misfolding and aggregation as seen in age-related neurodegenerative diseases. Sirtuin...
8.
Gosslau A, Li S, Ho C, Chen K, Rawson N
Mol Nutr Food Res
. 2011 Jan;
55(1):74-82.
PMID: 21207514
The knowledge that natural products provide a rich source for therapeutic discovery has led to the development of many of the world's most commonly used drugs. In view of the...
9.
Gosslau A, En Jao D, Huang M, Ho C, Evans D, Rawson N, et al.
Mol Nutr Food Res
. 2010 Jul;
55(2):198-208.
PMID: 20669245
Scope: Theaflavin-2 (TF-2), a major component of black tea extract, induces apoptosis of human colon cancer cells and suppresses serum-induced cyclooxygenase-2 (COX-2) expression 1. Here, we explored the mechanisms for...
10.
Gosslau A, Jao D, Butler R, Liu A, Chen K
J Cell Physiol
. 2009 Jan;
219(2):485-93.
PMID: 19160416
Heat-induced cell death appears to be a cell-specific event. Chronic heat stress was lethal to human colon cancer cells (Caco-2, HT29, and HCT116), but not to normal diploid fibroblasts and...