HSF1, Aging, and Neurodegeneration

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2022 Aug 22

PMID 35995906

Authors

Alice Y Liu

Conceicao A Minetti

David P Remeta

Kenneth J Breslauer

Kuang Yu Chen

Affiliations

Soon will be listed here.

Abstract

Objectives: Herein we discuss the regulation and function of HSF1 as they relate to the pathophysiological changes of protein quality control in aging and neurodegenerative diseases (ND).

Methods: We present an overview of HSF1 structural, functional, and energetic properties in healthy cells while addressing the deterioration of HSF1 function vis-à-vis age-dependent and neuron-specific vulnerability to neurodegenerative diseases.

Results: We examine the impact of intrinsically disordered regions on the function of HSF1 and note that proteins associated with neurodegeneration are natively unstructured and exquisitely sensitive to changes in cellular environment as may occur during aging.

Conclusions: We put forth a hypothesis that age-dependent changes of the intrinsically disordered proteome hold answers to understanding many of the functional, structural, and organizational changes of proteins - dysfunction of HSF1 in aging and appearance of disease protein aggregates in neurodegenerative diseases included.

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