Krzysztof M Zak
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Explore the profile of Krzysztof M Zak including associated specialties, affiliations and a list of published articles.
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20
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928
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Recent Articles
1.
Zak K, Waterson A, Geist L, Braun N, Hauer K, Rumpel K, et al.
J Med Chem
. 2025 Jan;
68(3):2680-2693.
PMID: 39818983
The Son of Sevenless (SOS) protein family includes two highly homologous proteins, SOS1 and SOS2, that act as guanine nucleotide exchange factors (GEFs) for RAS proteins. They catalyze the GDP-to-GTP...
2.
Munzker L, Kimani S, Fowkes M, Dong A, Zheng H, Li Y, et al.
Commun Biol
. 2024 Jul;
7(1):901.
PMID: 39048679
The WWE domain is a relatively under-researched domain found in twelve human proteins and characterized by a conserved tryptophan-tryptophan-glutamate (WWE) sequence motif. Six of these WWE domain-containing proteins also contain...
3.
Gerstberger T, Berger H, Buttner F, Gmachl M, Kessler D, Koegl M, et al.
J Med Chem
. 2024 Jul;
67(14):11701-11711.
PMID: 39009041
Identifying promising chemical starting points for small molecule inhibitors of active, GTP-loaded KRAS "on" remains of great importance to clinical oncology and represents a significant challenge in medicinal chemistry. Here,...
4.
Gaussmann S, Peschel R, Ott J, Zak K, Sastre J, Delhommel F, et al.
Nat Commun
. 2024 Apr;
15(1):3317.
PMID: 38632234
Import of proteins into peroxisomes depends on PEX5, PEX13 and PEX14. By combining biochemical methods and structural biology, we show that the C-terminal SH3 domain of PEX13 mediates intramolecular interactions...
5.
Bottcher J, Fuchs J, Mayer M, Kahmann J, Zak K, Wunberg T, et al.
Arch Pharm (Weinheim)
. 2024 Feb;
357(6):e2300649.
PMID: 38396281
Transcription factors are generally considered challenging, if not "undruggable", targets but they promise new therapeutic options due to their fundamental involvement in many diseases. In this study, we aim to...
6.
Wator E, Wilk P, Biela A, Rawski M, Zak K, Steinchen W, et al.
Nat Commun
. 2023 Mar;
14(1):1698.
PMID: 36973244
Hypusination is a unique post-translational modification of the eukaryotic translation factor 5A (eIF5A) that is essential for overcoming ribosome stalling at polyproline sequence stretches. The initial step of hypusination, the...
7.
Biebl M, Delhommel F, Faust O, Zak K, Agam G, Guo X, et al.
Mol Cell
. 2022 Jan;
82(3):555-569.e7.
PMID: 35063133
In the eukaryotic cytosol, the Hsp70 and the Hsp90 chaperone machines work in tandem with the maturation of a diverse array of client proteins. The transfer of nonnative clients between...
8.
Borchard S, Raschke S, Zak K, Eberhagen C, Einer C, Weber E, et al.
Life Sci Alliance
. 2021 Dec;
5(3).
PMID: 34857647
In Wilson disease, excessive copper accumulates in patients' livers and may, upon serum leakage, severely affect the brain according to current viewpoints. Present remedies aim at avoiding copper toxicity by...
9.
Zak K, Bostock M, Waligorska I, Thogersen I, Enghild J, Popowicz G, et al.
J Enzyme Inhib Med Chem
. 2021 Jul;
36(1):1267-1281.
PMID: 34210221
Mirolysin is a secretory protease of , a member of the dysbiotic oral microbiota responsible for periodontitis. In this study, we show that mirolysin latency is achieved by a "cysteine-switch"...
10.
Softley C, Zak K, Bostock M, Fino R, Zhou R, Kolonko M, et al.
Antimicrob Agents Chemother
. 2020 Jun;
64(7).
PMID: 32576598
No abstract available.