Grzegorz M Popowicz
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Explore the profile of Grzegorz M Popowicz including associated specialties, affiliations and a list of published articles.
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78
Citations
2888
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Recent Articles
1.
Lis K, Plewka J, Menezes F, Bielecka E, Chykunova Y, Pustelny K, et al.
Int J Biol Macromol
. 2024 Jul;
276(Pt 1):133473.
PMID: 39024924
No abstract available.
2.
Siebenmorgen T, Menezes F, Benassou S, Merdivan E, Didi K, Mourao A, et al.
Nat Comput Sci
. 2024 May;
4(5):367-378.
PMID: 38730184
Large language models have greatly enhanced our ability to understand biology and chemistry, yet robust methods for structure-based drug discovery, quantum chemistry and structural biology are still sparse. Precise biomolecule-ligand...
3.
Gaussmann S, Peschel R, Ott J, Zak K, Sastre J, Delhommel F, et al.
Nat Commun
. 2024 Apr;
15(1):3317.
PMID: 38632234
Import of proteins into peroxisomes depends on PEX5, PEX13 and PEX14. By combining biochemical methods and structural biology, we show that the C-terminal SH3 domain of PEX13 mediates intramolecular interactions...
4.
Lis K, Plewka J, Menezes F, Bielecka E, Chykunova Y, Pustelny K, et al.
Int J Biol Macromol
. 2024 Apr;
267(Pt 1):131392.
PMID: 38582483
The main protease (M) of SARS-CoV-2 is critical in the virus's replication cycle, facilitating the maturation of polyproteins into functional units. Due to its conservation across taxa, M is a...
5.
Matsuda A, Plewka J, Rawski M, Mourao A, Zajko W, Siebenmorgen T, et al.
Nucleic Acids Res
. 2024 Mar;
52(11):6441-6458.
PMID: 38499483
Coronaviruses modify their single-stranded RNA genome with a methylated cap during replication to mimic the eukaryotic mRNAs. The capping process is initiated by several nonstructural proteins (nsp) encoded in the...
6.
Giehler F, Ostertag M, Sommermann T, Weidl D, Sterz K, Kutz H, et al.
Nat Commun
. 2024 Jan;
15(1):414.
PMID: 38195569
Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) drives viral B cell transformation and oncogenesis. LMP1's transforming activity depends on its C-terminal activation region 2 (CTAR2), which induces NF-κB and...
7.
Kitel R, Surmiak E, Borggrafe J, Kalinowska-Tluscik J, Golik P, Czub M, et al.
J Med Chem
. 2023 Dec;
66(23):15715-15727.
PMID: 38039505
Here, we report the fragment-based drug discovery of potent and selective fragments that disrupt the Spire2-FMN2 but not the Spire1-FMN2 interaction. Hit fragments were identified in a differential scanning fluorimetry-based...
8.
Pustelny K, Grygier P, Barzowska A, Pucelik B, Matsuda A, Mrowiec K, et al.
Sci Rep
. 2023 Oct;
13(1):18114.
PMID: 37872245
The selective inhibition of kinases from the diabetic kinome is known to promote the regeneration of beta cells and provide an opportunity for the curative treatment of diabetes. The effect...
9.
Troisi R, Napolitano V, Rossitto E, Osman W, Nagano M, Wakui K, et al.
Nucleic Acids Res
. 2023 Jul;
51(16):8880-8890.
PMID: 37503836
Ligand/protein molecular recognition involves a dynamic process, whereby both partners require a degree of structural plasticity to regulate the binding/unbinding event. Here, we present the characterization of the interaction between...
10.
Marciniak M, Mroz P, Napolitano V, Kalel V, Fino R, Pykacz E, et al.
Eur J Med Chem
. 2023 Jul;
258:115587.
PMID: 37406382
Protein-protein interactions (PPIs) constitute an important but challenging class of molecular targets for small molecules. The PEX5-PEX14 PPI has been shown to play a critical role in glycosome biogenesis and...