Kousik Kesh
Overview
Explore the profile of Kousik Kesh including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
512
Followers
0
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Recent Articles
1.
Kesh K, Tao J, Ghosh N, Jalodia R, Singh S, Dawra R, et al.
Gut Microbes
. 2024 Feb;
16(1):2310291.
PMID: 38329115
Opioids, such as morphine and oxycodone, are widely used for pain management associated with chronic pancreatitis (CP); however, their impact on the progression and pain sensitivity of CP has never...
2.
Ghosh N, Kesh K, Singh P, Sharma U, Chupikova I, Ramakrishnan S, et al.
Br J Pharmacol
. 2022 Dec;
180(12):1582-1596.
PMID: 36585367
Background And Purpose: Opioids are the standard drug for pain management; however, their effects on gastric dysfunction are relatively understudied. Opioid users have a higher incidence of gastric pathology leading...
3.
Kesh K, Mendez R, Mateo-Victoriano B, Garrido V, Durden B, Gupta V, et al.
Gut Microbes
. 2022 Jul;
14(1):2096328.
PMID: 35816618
Obesity causes chronic inflammation and changes in gut microbiome. However, how this contributes to poor survival and therapy resistance in patients with pancreatic cancer remain undetermined. Our current study shows...
4.
Ghosh N, Kesh K, Ramakrishnan S, Roy S
Am J Pathol
. 2022 May;
192(8):1136-1150.
PMID: 35605643
Opioids are the gold standard for chronic and acute pain management; however, their consequence on gastric function is relatively understudied. Opioid users have a higher incidence of gastric dysfunction, worse...
5.
Gupta V, Sharma N, Durden B, Garrido V, Kesh K, Edwards D, et al.
Cancer Res
. 2021 May;
81(15):4001-4013.
PMID: 33990397
In pancreatic cancer, the robust fibroinflammatory stroma contributes to immune suppression and renders tumors hypoxic, altering intratumoral metabolic pathways and leading to poor survival. One metabolic enzyme activated during hypoxia...
6.
Kesh K, Garrido V, Dosch A, Durden B, Gupta V, Sharma N, et al.
Cell Death Dis
. 2020 Nov;
11(11):967.
PMID: 33177492
Pancreatic adenocarcinoma is a devastating disease with an abysmal survival rate of 9%. A robust fibro-inflammatory and desmoplastic stroma, characteristic of pancreatic cancer, contribute to the challenges in developing viable...
7.
Kesh K, Gupta V, Durden B, Garrido V, Mateo-Victoriano B, Lavania S, et al.
Cancers (Basel)
. 2020 Oct;
12(10).
PMID: 33096662
The extracellular matrix (ECM) has remained an enigmatic component of the tumor microenvironment. It drives metastasis via its interaction with the integrin signaling pathway, contributes to tumor progression and confers...
8.
Kesh K, Mendez R, Abdelrahman L, Banerjee S, Banerjee S
Microb Cell Fact
. 2020 Mar;
19(1):75.
PMID: 32204699
Resistance to therapy is one of the major factors that contribute to dismal survival statistics in pancreatic cancer. While there are many tumor intrinsic and tumor microenvironment driven factors that...
9.
Sharma N, Gnamlin P, Durden B, Gupta V, Kesh K, Garrido V, et al.
Oncogenesis
. 2019 Nov;
8(12):68.
PMID: 31740660
Presence of quiescent, therapy evasive population often described as cancer stem cells (CSC) or tumor initiating cells (TIC) is often attributed to extreme metastasis and tumor recurrence. This population is...
10.
Subramanian L, Maghajothi S, Singh M, Kesh K, Kalyani A, Sharma S, et al.
Hypertension
. 2019 Oct;
74(6):1448-1459.
PMID: 31656093
MMP (matrix metalloproteinase)-7-a potent extracellular matrix degrading enzyme-is emerging as a new regulator of cardiovascular diseases. However, potential contributions of genetic variations to hypertension remain unknown. In this study, we...