Therapy Resistance, Cancer Stem Cells and ECM in Cancer: The Matrix Reloaded

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2020 Oct 24

PMID 33096662

Citations 32

Authors

Kousik Kesh

Vineet K Gupta

Brittany Durden

Vanessa Garrido

Beatriz Mateo-Victoriano

Shweta P Lavania

Sulagna Banerjee

Affiliations

Soon will be listed here.

Abstract

The extracellular matrix (ECM) has remained an enigmatic component of the tumor microenvironment. It drives metastasis via its interaction with the integrin signaling pathway, contributes to tumor progression and confers therapy resistance by providing a physical barrier around the tumor. The complexity of the ECM lies in its heterogeneous composition and complex glycosylation that can provide a support matrix as well as trigger oncogenic signaling pathways by interacting with the tumor cells. In this review, we attempt to dissect the role of the ECM in enriching for the treatment refractory cancer stem cell population and how it may be involved in regulating their metabolic needs. Additionally, we discuss how the ECM is instrumental in remodeling the tumor immune microenvironment and the potential ways to target this component in order to develop a viable therapy.

Citing Articles

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