Ashok Saluja
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Explore the profile of Ashok Saluja including associated specialties, affiliations and a list of published articles.
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Articles
49
Citations
1522
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Recent Articles
1.
Lim S, Saluja A, Vickers S, Hong J, Kim S, Lavania S, et al.
Cancer Lett
. 2024 Jun;
597():217041.
PMID: 38866072
Minnelide is a water-soluble disodium salt variant of triptolide, an HSP70 inhibitor that can prevent tumor progression and induce apoptosis. Maximum tolerated dose (MTD), safety, and antitumor activity of Minnelide...
2.
Borazanci E, Saluja A, Gockerman J, Velagapudi M, Korn R, Von Hoff D, et al.
Oncologist
. 2024 Jan;
29(2):132-141.
PMID: 38169017
Background: Minnelide is a water-soluble prodrug of triptolide. Triptolide is an anticancer agent that targets cancer resistance through several mechanisms. Minnelide was evaluated in a phase I study in patients...
3.
Giri B, Sharma P, Jain T, Ferrantella A, Vaish U, Mehra S, et al.
Oncoimmunology
. 2021 Sep;
10(1):1976952.
PMID: 34552825
Heat shock protein 70 (Hsp70), a protein chaperone, is known to promote cell survival and tumor progression. However, its role in the tumor microenvironment (TME) is largely unknown. We specifically...
4.
Lavania S, Gupta V, Saluja A
Gastroenterology
. 2021 Jun;
161(3):804-806.
PMID: 34174244
No abstract available.
5.
Minnelide, a prodrug, inhibits cervical cancer growth by blocking HPV-induced changes in p53 and pRb
Ramakrishnan V, de Haydu C, Wilkinson P, Hooda U, Giri B, Oleas J, et al.
Am J Cancer Res
. 2021 Jun;
11(5):2202-2214.
PMID: 34094678
HPV-induced cervical cancer is one of the prevalent gynecological cancers world-wide. In the present study, we determined the efficacy of Minnelide, a prodrug which is converted to its active form...
6.
Gupta V, Sharma N, Durden B, Garrido V, Kesh K, Edwards D, et al.
Cancer Res
. 2021 May;
81(15):4001-4013.
PMID: 33990397
In pancreatic cancer, the robust fibroinflammatory stroma contributes to immune suppression and renders tumors hypoxic, altering intratumoral metabolic pathways and leading to poor survival. One metabolic enzyme activated during hypoxia...
7.
Kesh K, Garrido V, Dosch A, Durden B, Gupta V, Sharma N, et al.
Cell Death Dis
. 2020 Nov;
11(11):967.
PMID: 33177492
Pancreatic adenocarcinoma is a devastating disease with an abysmal survival rate of 9%. A robust fibro-inflammatory and desmoplastic stroma, characteristic of pancreatic cancer, contribute to the challenges in developing viable...
8.
Giri B, Ferrantella A, Sharma P, Jain T, Jacob H, Modi S, et al.
J Gastrointest Surg
. 2020 Jun;
25(5):1271-1279.
PMID: 32542554
Background: Even after surgical resection, most patients with localized pancreatic ductal adenocarcinoma (PDAC) succumb to disease recurrence. Current animal models do not recapitulate this pattern of disease recurrence. Our goal...
9.
Esposito I, Hruban R, Verbeke C, Terris B, Zamboni G, Scarpa A, et al.
Pancreatology
. 2020 May;
20(4):586-593.
PMID: 32414657
Background: Chronic pancreatitis is a complex multifactorial fibro-inflammatory disease. Consensus guidelines are needed for the histopathological evaluation of non-autoimmune chronic pancreatitis (CP). Methods: An international working group with experts on...
10.
Sharma N, Gnamlin P, Durden B, Gupta V, Kesh K, Garrido V, et al.
Oncogenesis
. 2019 Nov;
8(12):68.
PMID: 31740660
Presence of quiescent, therapy evasive population often described as cancer stem cells (CSC) or tumor initiating cells (TIC) is often attributed to extreme metastasis and tumor recurrence. This population is...