Small Silencing RNAs: Piecing Together a Viral Genome

Overview

Journal Cell Host Microbe

Publisher Cell Press

Specialties Infectious Diseases
Microbiology

Date 2010 Feb 18

PMID 20159613

Citations 7

Authors

Joel T van Mierlo

Koen W R van Cleef

Ronald P van Rij

Affiliations

Soon will be listed here.

Abstract

Virus-derived small interfering RNAs (siRNAs) are the hallmark of RNAi-based antiviral immunity. Wu and colleagues demonstrate how viral genomes can be assembled from these small RNA sequences. Their results provide an approach for virus discovery as well as important insights into how these siRNAs mediate antiviral defense.

Citing Articles

Infection Defects of RNA and DNA Viruses Induced by Antiviral RNA Interference.

Liu S, Han Y, Li W, Ding S Microbiol Mol Biol Rev. 2023; 87(2):e0003522.

PMID: 37052496 PMC: 10304667. DOI: 10.1128/mmbr.00035-22.

Identification, Characterization and Full-Length Sequence Analysis of a Novel Polerovirus Associated with Wheat Leaf Yellowing Disease.

Zhang P, Liu Y, Liu W, Cao M, Massart S, Wang X Front Microbiol. 2017; 8:1689.

PMID: 28932215 PMC: 5592212. DOI: 10.3389/fmicb.2017.01689.

Israeli Acute Paralysis Virus Infection Leads to an Enhanced RNA Interference Response and Not Its Suppression in the Bumblebee Bombus terrestris.

Cappelle K, Smagghe G, Dhaenens M, Meeus I Viruses. 2016; 8(12).

PMID: 27999371 PMC: 5192395. DOI: 10.3390/v8120334.

An efficient strategy of screening for pathogens in wild-caught ticks and mosquitoes by reusing small RNA deep sequencing data.

Zhuang L, Zhang Z, An X, Fan H, Ma M, Anderson B PLoS One. 2014; 9(3):e90831.

PMID: 24618575 PMC: 3949703. DOI: 10.1371/journal.pone.0090831.

Small RNAs tackle large viruses: RNA interference-based antiviral defense against DNA viruses in insects.

Bronkhorst A, Miesen P, van Rij R Fly (Austin). 2013; 7(4):216-23.

PMID: 23974177 PMC: 3896492. DOI: 10.4161/fly.25708.