Kit Briant
Overview
Explore the profile of Kit Briant including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
75
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0
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Recent Articles
1.
Greig J, Bates G, Yin D, Briant K, Simonetti B, Cullen P, et al.
EMBO J
. 2024 Aug;
43(19):4298-4323.
PMID: 39160272
The two clathrin isoforms, CHC17 and CHC22, mediate separate intracellular transport routes. CHC17 performs endocytosis and housekeeping membrane traffic in all cells. CHC22, expressed most highly in skeletal muscle, shuttles...
2.
Chen Y, Briant K, Camus M, Brodsky F
Life Sci Alliance
. 2023 Nov;
7(1).
PMID: 37923360
To identify functional differences between vertebrate clathrin light chains (CLCa or CLCb), phenotypes of mice lacking genes encoding either isoform were characterised. Mice without CLCa displayed 50% neonatal mortality, reduced...
3.
Redlingshofer L, McLeod F, Chen Y, Camus M, Burden J, Palomer E, et al.
Proc Natl Acad Sci U S A
. 2020 Sep;
117(38):23527-23538.
PMID: 32907943
Clathrin light chain (CLC) subunits in vertebrates are encoded by paralogous genes and , and both gene products are alternatively spliced in neurons. To understand how this CLC diversity influences...
4.
Briant K, Redlingshofer L, Brodsky F
Curr Opin Cell Biol
. 2020 Aug;
65:141-149.
PMID: 32836101
Understanding of the range and mechanisms of clathrin functions has developed exponentially since clathrin's discovery in 1975. Here, newly established molecular mechanisms that regulate clathrin activity and connect clathrin pathways...
5.
Dannhauser P, Camus S, Sakamoto K, Sadacca L, Torres J, Camus M, et al.
J Biol Chem
. 2017 Nov;
292(51):20834-20844.
PMID: 29097553
Clathrins are cytoplasmic proteins that play essential roles in endocytosis and other membrane traffic pathways. Upon recruitment to intracellular membranes, the canonical clathrin triskelion assembles into a polyhedral protein coat...
6.
Briant K, Johnson N, Swanton E
PLoS One
. 2017 Apr;
12(4):e0173924.
PMID: 28384259
Multiple protein quality control systems operate to ensure that misfolded proteins are efficiently cleared from the cell. While quality control systems that assess the folding status of soluble domains have...
7.
Uggenti C, Briant K, Streit A, Thomson S, Koay Y, Baines R, et al.
Dis Model Mech
. 2016 Aug;
9(11):1317-1328.
PMID: 27519691
Autosomal recessive bestrophinopathy (ARB) is a retinopathy caused by mutations in the bestrophin-1 protein, which is thought to function as a Ca-gated Cl channel in the basolateral surface of the...
8.
Briant K, Koay Y, Otsuka Y, Swanton E
J Cell Sci
. 2015 Oct;
128(22):4112-25.
PMID: 26446255
Clearance of misfolded proteins from the endoplasmic reticulum (ER) is mediated by the ubiquitin-proteasome system in a process known as ER-associated degradation (ERAD). The mechanisms through which proteins containing aberrant...