Frances M Brodsky
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Explore the profile of Frances M Brodsky including associated specialties, affiliations and a list of published articles.
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63
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2493
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Recent Articles
1.
Greig J, Bates G, Yin D, Briant K, Simonetti B, Cullen P, et al.
EMBO J
. 2024 Aug;
43(19):4298-4323.
PMID: 39160272
The two clathrin isoforms, CHC17 and CHC22, mediate separate intracellular transport routes. CHC17 performs endocytosis and housekeeping membrane traffic in all cells. CHC22, expressed most highly in skeletal muscle, shuttles...
2.
Abela L, Gianfrancesco L, Tagliatti E, Rossignoli G, Barwick K, Zourray C, et al.
Brain
. 2024 Jan;
147(6):2023-2037.
PMID: 38242634
DNAJC6 encodes auxilin, a co-chaperone protein involved in clathrin-mediated endocytosis (CME) at the presynaptic terminal. Biallelic mutations in DNAJC6 cause a complex, early-onset neurodegenerative disorder characterized by rapidly progressive parkinsonism-dystonia...
3.
Chen Y, Briant K, Camus M, Brodsky F
Life Sci Alliance
. 2023 Nov;
7(1).
PMID: 37923360
To identify functional differences between vertebrate clathrin light chains (CLCa or CLCb), phenotypes of mice lacking genes encoding either isoform were characterised. Mice without CLCa displayed 50% neonatal mortality, reduced...
4.
Duan X, Norris D, Humphrey S, Yang P, Cooke K, Bultitude W, et al.
Biochem J
. 2022 May;
479(11):1237-1256.
PMID: 35594055
Trafficking regulator of GLUT4-1, TRARG1, positively regulates insulin-stimulated GLUT4 trafficking and insulin sensitivity. However, the mechanism(s) by which this occurs remain(s) unclear. Using biochemical and mass spectrometry analyses we found...
5.
Redlingshofer L, Brodsky F
Cells Dev
. 2021 Jun;
168:203714.
PMID: 34182181
Orchestration of a complex network of protein interactions drives clathrin-mediated endocytosis (CME). A central role for the AP2 adaptor complex beyond cargo recognition and clathrin recruitment has emerged in recent...
6.
Marks M, Parton R, Schroer T, Tooze S, Brodsky F, Marsh M, et al.
Traffic
. 2020 Nov;
21(12):724.
PMID: 33190364
No abstract available.
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Redlingshofer L, McLeod F, Chen Y, Camus M, Burden J, Palomer E, et al.
Proc Natl Acad Sci U S A
. 2020 Sep;
117(38):23527-23538.
PMID: 32907943
Clathrin light chain (CLC) subunits in vertebrates are encoded by paralogous genes and , and both gene products are alternatively spliced in neurons. To understand how this CLC diversity influences...
10.
Briant K, Redlingshofer L, Brodsky F
Curr Opin Cell Biol
. 2020 Aug;
65:141-149.
PMID: 32836101
Understanding of the range and mechanisms of clathrin functions has developed exponentially since clathrin's discovery in 1975. Here, newly established molecular mechanisms that regulate clathrin activity and connect clathrin pathways...