Kim D Falkenberg
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Explore the profile of Kim D Falkenberg including associated specialties, affiliations and a list of published articles.
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12
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968
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Recent Articles
1.
Conchinha N, Sokol L, Teuwen L, Veys K, Dumas S, Meta E, et al.
STAR Protoc
. 2021 Sep;
2(3):100508.
PMID: 34585146
Endothelial cells (ECs) harbor distinct phenotypical and functional characteristics depending on their tissue localization and contribute to brain, eye, lung, and muscle diseases such as dementia, macular degeneration, pulmonary hypertension,...
2.
Dumas S, Meta E, Conchinha N, Sokol L, Chen R, Borri M, et al.
STAR Protoc
. 2021 Aug;
2(3):100523.
PMID: 34382011
Endothelial cells (ECs) exhibit phenotypic and functional tissue specificities, critical for studies in the vascular field and beyond. Thus, tissue-specific methods for isolation of highly purified ECs are necessary. Kidney,...
3.
Sokol L, Geldhof V, Garcia-Caballero M, Conchinha N, Dumas S, Meta E, et al.
STAR Protoc
. 2021 May;
2(2):100489.
PMID: 34007969
Endothelial cells (ECs) from the small intestine, colon, liver, and heart have distinct phenotypes and functional adaptations that are dependent on their physiological environment. Gut ECs adapt to low oxygen,...
4.
Klouwer F, Falkenberg K, Ofman R, Koster J, van Gent D, Ferdinandusse S, et al.
Front Cell Dev Biol
. 2021 Apr;
9:661298.
PMID: 33869228
Peroxisome biogenesis disorders within the Zellweger spectrum (PBD-ZSDs) are most frequently associated with the c.2528G>A (p.G843D) mutation in the gene (PEX1-G843D), which results in impaired import of peroxisomal matrix proteins...
5.
Falkenberg K, Rohlenova K, Luo Y, Carmeliet P
Nat Metab
. 2020 Jul;
1(10):937-946.
PMID: 32694836
Endothelial cells (ECs) line the quiescent vasculature but can form new blood vessels (a process termed angiogenesis) in disease. Strategies targeting angiogenic growth factors have been clinically developed for the...
6.
Rohlenova K, Goveia J, Garcia-Caballero M, Subramanian A, Kalucka J, Treps L, et al.
Cell Metab
. 2020 Apr;
31(4):862-877.e14.
PMID: 32268117
Endothelial cell (EC) metabolism is an emerging target for anti-angiogenic therapy in tumor angiogenesis and choroidal neovascularization (CNV), but little is known about individual EC metabolic transcriptomes. By single-cell RNA...
7.
Kalucka J, de Rooij L, Goveia J, Rohlenova K, Dumas S, Meta E, et al.
Cell
. 2020 Feb;
180(4):764-779.e20.
PMID: 32059779
The heterogeneity of endothelial cells (ECs) across tissues remains incompletely inventoried. We constructed an atlas of >32,000 single-EC transcriptomes from 11 mouse tissues and identified 78 EC subclusters, including Aqp7...
8.
Falkenberg K, Braverman N, Moser A, Steinberg S, Klouwer F, Schluter A, et al.
Am J Hum Genet
. 2017 Dec;
101(6):965-976.
PMID: 29220678
Zellweger spectrum disorders (ZSDs) are autosomal-recessive disorders that are caused by defects in peroxisome biogenesis due to bi-allelic mutations in any of 13 different PEX genes. Here, we identified seven...
9.
Biochemical and genetic characterization of an unusual mild PEX3-related Zellweger spectrum disorder
Bjorgo K, Fjaer R, Mork H, Ferdinandusse S, Falkenberg K, Waterham H, et al.
Mol Genet Metab
. 2017 Jul;
121(4):325-328.
PMID: 28673549
Patients with PEX3 mutations usually present with a severe form of Zellweger spectrum disorder with death in the first year of life. Whole exome sequencing in adult siblings with intellectual...
10.
Falkenberg K, Jakobs A, Matern J, Dorner W, Uttarkar S, Trentmann A, et al.
Biochim Biophys Acta Mol Cell Res
. 2017 May;
1864(7):1349-1358.
PMID: 28476645
Recent work has shown that deregulation of the transcription factor Myb contributes to the development of leukemia and several other human cancers, making Myb and its cooperation partners attractive targets...