Kim C Mansky
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Explore the profile of Kim C Mansky including associated specialties, affiliations and a list of published articles.
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43
Citations
761
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Recent Articles
1.
Astleford-Hopper K, Abrahante Llorens J, Bradley E, Mansky K
JBMR Plus
. 2024 Dec;
9(1):ziae142.
PMID: 39664933
Osteoclasts are large multinucleated cells that degrade bone mineral and extracellular matrix. Investigating the epigenetic mechanisms orchestrating osteoclast differentiation is key to our understanding of the pathogenesis of skeletal related...
2.
Koroth J, Karkache I, Vu E, Mansky K, Bradley E
bioRxiv
. 2024 Sep;
PMID: 39314303
Disruptions in the bone remodeling cycle that occur with increasing age lead to degeneration of the skeleton and increased risk of fragility fractures. Our understanding of how bone remodeling within...
3.
Zhang Z, Huang Z, Awad M, Elsalanty M, Cray J, Ball L, et al.
Elife
. 2023 Mar;
12.
PMID: 36861967
In mammals, interactions between the bone marrow (BM) stroma and hematopoietic progenitors contribute to bone-BM homeostasis. Perinatal bone growth and ossification provide a microenvironment for the transition to definitive hematopoiesis;...
4.
Norton A, Thieu K, Baumann C, Lowe D, Mansky K
Sci Rep
. 2022 Sep;
12(1):15900.
PMID: 36151243
Osteoporosis and sarcopenia are maladies of aging that negatively affect more women than men. In recent years, it has become apparent that bone and muscle are coupled not only mechanically...
5.
Meyers C, Burciaga S, Faulkner B, Kazemi P, Cohn J, Mansky K, et al.
Bone
. 2022 Mar;
159:116393.
PMID: 35318161
Protein kinase D (PRKD) family kinases are required for formation and function of osteoclasts. However, the substrates of PRKD in osteoclasts are unknown. To identify PRKD-dependent protein phosphorylation in osteoclasts,...
6.
Karkache I, Damodaran J, Molstad D, Mansky K, Bradley E
Int J Mol Sci
. 2021 Sep;
22(18).
PMID: 34575866
Prior work demonstrated that Phlpp1 deficiency alters trabecular bone mass and enhances M-CSF responsiveness, but the cell types and requirement of Phlpp1 for this effect were unclear. To understand the...
7.
Chatzopoulos G, Costalonga M, Mansky K, Wolff L
Medicina (Kaunas)
. 2021 Aug;
57(8).
PMID: 34440994
Wnt signaling leads to stimulation of osteoblasts and it reduces osteoclastogenesis and bone resorption via the regulation of the osteprotegrin and receptor activator of nuclear factor kappa-Β ligan (RANKL). Wnt...
8.
Hanson M, Karkache I, Molstad D, Norton A, Mansky K, Bradley E
PLoS One
. 2021 Jun;
16(6):e0251732.
PMID: 34143773
Prior studies demonstrated that deletion of the protein phosphatase Phlpp1 in Ctsk-Cre expressing cells enhances bone mass, characterized by diminished osteoclast activity and increased coupling to bone formation. Due to...
9.
Fischer N, Chen X, Astleford-Hopper K, He J, Mullikin A, Mansky K, et al.
Mater Sci Eng C Mater Biol Appl
. 2021 May;
125:112108.
PMID: 33965114
Functionalization of dental and orthopedic implants with multiple bioactivities is desirable to obtain surfaces with improved biological performance and reduced infection rates. While many approaches have been explored to date,...
10.
Molstad D, Zars E, Norton A, Mansky K, Westendorf J, Bradley E
Sci Rep
. 2020 Dec;
10(1):21804.
PMID: 33311522
Previous studies examining the role of the histone deacetylase Hdac3 within myeloid cells demonstrated that Hdac3 promotes M2 activation and tissue healing in inflammatory conditions. Since myeloid lineage cells are...