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» Authors » Rajaram Gopalakrishnan

Rajaram Gopalakrishnan

Explore the profile of Rajaram Gopalakrishnan including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 67
Citations 1860
Followers 0
Related Specialties
Biochemistry
Pathology
Dentistry
Top 10 Co-Authors
Ioannis G Koutlas
Eric D Jensen
Prokopios P Argyris
Kim C Mansky
Anna Petryk
Renny T Franceschi
Pamela J Hughes
Charles J Billington Jr
Vivek Thumbigere-Math
Ann E Carlson
Published In
Head Neck Pathol
J Cell Biochem
J Oral Maxillofac Surg
Oral Surg Oral Med Oral Pathol Oral Radiol
J Biol Chem
Affiliations
Soon will be listed here.
Recent Articles
1.
Intraoral salivary lymphoepithelial carcinoma: clinicopathologic and immunophenotypic characterization of 3 cases indicates elevated programmed death-ligand 1 expression
Argyris P, Lukenda C, Racila E, Midtling J, Ahmad M, Gopalakrishnan R, et al.
Oral Surg Oral Med Oral Pathol Oral Radiol . 2023 Sep; 136(5):623-631. PMID: 37770328
Objective: Intraoral salivary lymphoepithelial carcinoma (ISLEC) is a rare malignancy with programmed death-ligand 1 (PD-L1) expression levels that have been greatly understudied. We examined the clinicopathologic and immunophenotypic characteristics, including...
2.
An Unusual Gingival (Peripheral) Tumor with Features of Keratoameloblastoma with Cytologic Atypia or Possible Malignant Transformation Exhibiting ARID1A Mutation
Stojanov I, Ho D, Huss J, Gopalakrishnan R, Yoest J, Koutlas I
Head Neck Pathol . 2023 May; 17(3):808-814. PMID: 37195520
Background: Keratoameloblastoma is a poorly characterized and rarely reported odontogenic neoplasm that can exhibit overlapping histopathologic features with conventional ameloblastoma and keratocystic odontogenic tumor (KCOT), with an ambiguous relationship to...
3.
Primary mucosal melanomas of the head and neck are characterised by overexpression of the DNA mutating enzyme APOBEC3B
Argyris P, Naumann J, Jarvis M, Wilkinson P, Ho D, Islam M, et al.
Histopathology . 2022 Nov; 82(4):608-621. PMID: 36416305
Aims: Primary head/neck mucosal melanomas (MMs) are rare and exhibit aggressive biologic behaviour and elevated mutational loads. The molecular mechanisms responsible for high genomic instability observed in head/neck MMs remain...
4.
Metastatic Tumors to the Oral Soft Tissues and Jawbones: A Retrospective Analysis of 40 Cases and Review of the Literature
Ho D, Wilkinson P, Vogel R, Gopalakrishnan R, Argyris P
Head Neck Pathol . 2022 Apr; 16(3):802-813. PMID: 35438419
Background: Metastasis to the oral soft tissues and jawbones is rare and frequently associated with wide spread disease and dismal prognosis. Herein, we report the clinicopathologic characteristics of 40 intraoral...
5.
Whole Exome Sequencing Identifies Somatic Variants in an Oral Composite Hemangioendothelioma Characterized by YAP1-MAML2 Fusion
Koutlas I, Oetting W, Burns G, Gopalakrishnan R, Antonescu C
Head Neck Pathol . 2021 Nov; 16(3):849-856. PMID: 34791601
Composite hemangioendothelioma (CHE) is considered a borderline malignant vascular tumor defined by an admixture of distinct vascular neoplastic components. A 21-year-old female is presented herein with a 1 cm painless...
6.
Self-regressing oral CD30-positive, EBV-negative, T-cell lymphoproliferative lesions. A poorly understood process highlighted by ominous clinicopathologic features and indolent behavior
Argyris P, Ho D, Islam M, Khurram S, Courville E, Morgan S, et al.
Oral Surg Oral Med Oral Pathol Oral Radiol . 2021 Sep; 132(6):698-707. PMID: 34526251
Objective: Intraoral, primary, CD30-positive (CD30) T-cell lymphoproliferative disorders (TLPDs) are uncommon, and their clinicopathologic presentation and management can vary and may be challenging. Herein, we present a retrospective study of...
7.
Endogenous APOBEC3B overexpression characterizes HPV-positive and HPV-negative oral epithelial dysplasias and head and neck cancers
Argyris P, Wilkinson P, Jarvis M, Magliocca K, Patel M, Vogel R, et al.
Mod Pathol . 2020 Jul; 34(2):280-290. PMID: 32632179
The DNA cytosine deaminase APOBEC3B (A3B) is a newly recognized endogenous source of mutations in a range of human tumors, including head/neck cancer. A3B inflicts C-to-T and C-to-G base substitutions...
8.
Loss of myocyte enhancer factor 2 expression in osteoclasts leads to opposing skeletal phenotypes
Blixt N, Norton A, Zhang A, Aparicio C, Prasad H, Gopalakrishnan R, et al.
Bone . 2020 Jun; 138:115466. PMID: 32512162
Osteoclasts are multinuclear cells that resorb bone. Osteoclast differentiation is regulated by multiple transcription factors which may be acting in a single or multiple factor complex to regulate gene expression....
9.
Regulation of Osteoclast Differentiation at Multiple Stages by Protein Kinase D Family Kinases
Leightner A, Meyers C, Evans M, Mansky K, Gopalakrishnan R, Jensen E
Int J Mol Sci . 2020 Feb; 21(3). PMID: 32033440
Balanced osteoclast and osteoblast activity is necessary for skeletal health, whereas unbalanced osteoclast activity causes bone loss in many skeletal conditions. A better understanding of pathways that regulate osteoclast differentiation...
10.
Primary Intraosseous Xanthomas of the Jaws: A Series of Six Cases Including an Example with Formation of Apoptosis-Related Hyaline Globules, So-Called "Thanatosomes"
Wilkinson P, Merkourea S, Gopalakrishnan R, Argyris P
Head Neck Pathol . 2020 Jan; 14(4):859-868. PMID: 31916206
Primary intraosseous xanthomas of the jaws (PIXJ) are rare and predominantly affect the posterior mandible (86%) of normolipemic patients, with a mean age of 30 years and no gender predilection....