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Kristina Astleford

Explore the profile of Kristina Astleford including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Astleford K, Campbell E, Norton A, Mansky K
Int J Mol Sci . 2020 Sep; 21(19). PMID: 32992908
Age related changes to the skeleton, such as osteoporosis, increase the risk of fracture and morbidity in the elderly population. In osteoporosis, bone remodeling becomes unbalanced with an increase in...
2.
Faulkner B, Astleford K, Mansky K
Molecules . 2019 Apr; 24(7). PMID: 30959867
Bone is a dynamic tissue that must respond to developmental, repair, and remodeling cues in a rapid manner with changes in gene expression. Carefully-coordinated cycles of bone resorption and formation...
3.
Tasca A, Astleford K, Blixt N, Jensen E, Gopalakrishnan R, Mansky K
PLoS One . 2018 Sep; 13(9):e0203404. PMID: 30188920
Bone remodeling occurs via coupling between bone resorption by osteoclasts and bone formation by osteoblasts. The mechanisms that regulate osteoclast signals to osteoblasts are not well understood. Published studies have...
4.
Aukes K, Forsman C, Brady N, Astleford K, Blixt N, Sachdev D, et al.
PLoS One . 2017 Oct; 12(10):e0185736. PMID: 28968431
Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been implicated in promoting breast cancer growth and progression. While the autocrine effects of FGFR activation in tumor cells have been...
5.
Blixt N, Faulkner B, Astleford K, Lelich R, Schering J, Spencer E, et al.
PLoS One . 2017 Sep; 12(9):e0185441. PMID: 28953929
Histone deacetylases (HDACs) are negative regulators of transcription and have been shown to regulate specific changes in gene expression. In vertebrates, eighteen HDACs have thus far been identified and subdivided...
6.
Tasca A, Astleford K, Lederman A, Jensen E, Lee B, Gopalakrishnan R, et al.
Sci Rep . 2017 Aug; 7(1):7603. PMID: 28790434
Osteoclasts begin as mononuclear cells that fuse to form multinuclear cells able to resorb bone. The mechanisms that regulate all the steps of osteoclast differentiation are not entirely known. MYO10,...