Kieran F Geoghegan
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Explore the profile of Kieran F Geoghegan including associated specialties, affiliations and a list of published articles.
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1276
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Recent Articles
11.
Ahn K, Boehm M, Brown M, Calloway J, Che Y, Chen J, et al.
ACS Chem Biol
. 2016 Jul;
11(9):2529-40.
PMID: 27391855
Lysophospholipase-like 1 (LYPLAL1) is an uncharacterized metabolic serine hydrolase. Human genome-wide association studies link variants of the gene encoding this enzyme to fat distribution, waist-to-hip ratio, and nonalcoholic fatty liver...
12.
Ballard T, Dahal U, Bessire A, Schneider R, Geoghegan K, Vaz A
Rapid Commun Mass Spectrom
. 2015 Oct;
29(22):2175-83.
PMID: 26467230
Rationale: The covalent modification of proteins by toxicants, new chemical entities or drug molecules, either by metabolic activation or the presence of inherently reactive functional groups, is commonly implicated in...
13.
Schwaid A, Su C, Loos P, Wu J, Nguyen C, Stone K, et al.
ACS Chem Biol
. 2015 Oct;
10(12):2667-71.
PMID: 26422651
Mitogen-activated protein kinase 4 (MAP4K4) regulates the MEK kinase cascade and is implicated in cytoskeletal rearrangement and migration; however, identifying MAP4K4 substrates has remained a challenge. To ascertain MAP4K4-dependent phosphorylation...
14.
Xu H, Hett E, Gopalsamy A, Parikh M, Geoghegan K, Kyne Jr R, et al.
Mol Biosyst
. 2015 May;
11(10):2709-12.
PMID: 25959423
Despite its diverse applications, such as identification of the protein binding partners of small molecules and investigation of intracellular drug-target engagement, photoaffinity labelling (PAL) is intrinsically challenging, primarily due to...
15.
Cedervall P, Aulabaugh A, Geoghegan K, McLellan T, Pandit J
Proc Natl Acad Sci U S A
. 2015 Mar;
112(12):E1414-22.
PMID: 25775568
Phosphodiesterase 4 (PDE4) is an essential contributor to intracellular signaling and an important drug target. The four members of this enzyme family (PDE4A to -D) are functional dimers in which...
16.
Hett E, Xu H, Geoghegan K, Gopalsamy A, Kyne Jr R, Menard C, et al.
ACS Chem Biol
. 2015 Jan;
10(4):1094-8.
PMID: 25571984
This work describes the first rational targeting of tyrosine residues in a protein binding site by small-molecule covalent probes. Specific tyrosine residues in the active site of the mRNA-decapping scavenger...
17.
Schulke J, McAllister L, Geoghegan K, Parikh V, Chappie T, Verhoest P, et al.
ACS Chem Biol
. 2014 Oct;
9(12):2823-32.
PMID: 25295858
Phosphodiesterases (PDEs) regulate the levels of the second messengers cAMP and cGMP and are important drug targets. PDE10A is highly enriched in medium spiny neurons of the striatum and is...
18.
Calabrese M, Rajamohan F, Harris M, Caspers N, Magyar R, Withka J, et al.
Structure
. 2014 Jul;
22(8):1161-1172.
PMID: 25066137
AMP-activated protein kinase (AMPK) is a principal metabolic regulator affecting growth and response to cellular stress. Comprised of catalytic and regulatory subunits, each present in multiple forms, AMPK is best...
19.
Silva R, Geoghegan K, Qiu X, Aulabaugh A
Anal Biochem
. 2014 Jan;
450:63-9.
PMID: 24463014
Leucine-rich repeat kinase 2 (LRRK2) is a multi-domain enzyme displaying activities of GTP hydrolase and protein threonine/serine kinase in separate domains. Mutations in both catalytic domains have been linked to...
20.
Wu J, Puppala D, Feng X, Monetti M, Lapworth A, Geoghegan K
J Biol Chem
. 2013 Nov;
288(50):35904-12.
PMID: 24187138
AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme that senses and governs changes in the cellular energy balance represented by concentrations of AMP, ADP, and ATP. Each of its three...