Kevin Rouault-Pierre
Overview
Explore the profile of Kevin Rouault-Pierre including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
669
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Recent Articles
1.
Philippe C, Burke S, Rouault-Pierre K
J Vis Exp
. 2025 Jan;
215.
PMID: 39878938
Erythropoiesis, a remarkably dynamic and efficient process responsible for generating the daily quota of red blood cells (approximately 280 ± 20 billion cells per day), is crucial for maintaining individual...
2.
3.
Dembitz V, Lawson H, Burt R, Natani S, Philippe C, James S, et al.
Leukemia
. 2024 Aug;
38(11):2395-2409.
PMID: 39187579
Identification of specific and therapeutically actionable vulnerabilities, ideally present across multiple mutational backgrounds, is needed to improve acute myeloid leukemia (AML) patients' outcomes. We identify stearoyl-CoA desaturase (SCD), the key...
4.
Philippe C, Jaud M, Feral K, Gay A, Van Den Berghe L, Farce M, et al.
Leukemia
. 2024 Jun;
38(8):1764-1776.
PMID: 38909090
Malignant growth relies on rapid protein synthesis frequently leading to endoplasmic reticulum (ER) overload and accumulation of unfolded or misfolded protein in this cellular compartment. In the ER, protein homeostasis...
5.
Choi I, Ling J, Zhang J, Helmenstine E, Walter W, Tsakiroglou P, et al.
Blood Adv
. 2024 May;
8(15):3961-3971.
PMID: 38759096
Among the most common genetic alterations in myelodysplastic syndromes (MDS) are mutations in the spliceosome gene SF3B1. Such mutations induce specific RNA missplicing events, directly promote ring sideroblast (RS) formation,...
6.
Saunderson E, Huerga Encabo H, Devis J, Rouault-Pierre K, Piganeau M, Bell C, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(34):e2300224120.
PMID: 37579157
Aging is associated with an abnormal increase in DNA methylation (DNAm) in human gene promoters, including in bone marrow stem cells. DNAm patterns are further perturbed in hematological malignancies such...
7.
Choi I, Ling J, Zhang J, Helmenstine E, Walter W, Bergman R, et al.
Res Sq
. 2023 Apr;
PMID: 37090662
Among the most common genetic alterations in the myelodysplastic syndromes (MDS) are mutations in the spliceosome gene . Such mutations induce specific RNA missplicing events, directly promote ring sideroblast (RS)...
8.
Woodley K, Dillingh L, Giotopoulos G, Madrigal P, Rattigan K, Philippe C, et al.
Nat Commun
. 2023 Apr;
14(1):2132.
PMID: 37059720
Resistance to standard and novel therapies remains the main obstacle to cure in acute myeloid leukaemia (AML) and is often driven by metabolic adaptations which are therapeutically actionable. Here we...
9.
Mian S, Philippe C, Maniati E, Protopapa P, Bergot T, Piganeau M, et al.
Sci Transl Med
. 2023 Mar;
15(685):eabn5135.
PMID: 36857430
Patients with myelodysplastic syndrome and ring sideroblasts (MDS-RS) present with symptomatic anemia due to ineffective erythropoiesis that impedes their quality of life and increases morbidity. More than 80% of patients...
10.
Casado P, Rio-Machin A, Miettinen J, Bewicke-Copley F, Rouault-Pierre K, Krizsan S, et al.
Signal Transduct Target Ther
. 2023 Feb;
8(1):80.
PMID: 36843114
Acute myeloid leukaemia (AML) patients harbouring certain chromosome abnormalities have particularly adverse prognosis. For these patients, targeted therapies have not yet made a significant clinical impact. To understand the molecular...