Kevin I Watt
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Explore the profile of Kevin I Watt including associated specialties, affiliations and a list of published articles.
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21
Citations
775
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Recent Articles
1.
Wang P, Ahmed M, Nguyen N, Menendez-Montes I, Hsu C, Farag A, et al.
J Clin Invest
. 2025 Feb;
135(4).
PMID: 39959972
Dilated cardiomyopathy (DCM) due to genetic disorders results in decreased myocardial contractility, leading to high morbidity and mortality rates. There are several therapeutic challenges in treating DCM, including poor understanding...
2.
Keating M, Yang C, Liu Y, Gould E, Hallam M, Henstridge D, et al.
Mol Metab
. 2024 Oct;
90():102041.
PMID: 39362601
Objective: Dysregulation of hepatic cholesterol metabolism can contribute to elevated circulating cholesterol levels, which is a significant risk factor for cardiovascular disease. Cholesterol homeostasis in mammalian cells is tightly regulated...
3.
Hjorth M, Egan C, Telles G, Pal M, Gallego-Ortega D, Fuller O, et al.
J Sport Health Sci
. 2024 Sep;
14:100991.
PMID: 39341495
Purpose: Regular exercise can reduce incidence and progression of breast cancer, but the mechanisms for such effects are not fully understood. The purpose of this study was to examine the...
4.
McNamara J, Parker B, Voges H, Mehdiabadi N, Bolk F, Ahmad F, et al.
Nat Cardiovasc Res
. 2024 Aug;
2(2):159-173.
PMID: 39196058
Muscle contraction is driven by the molecular machinery of the sarcomere. As phosphorylation is a critical regulator of muscle function, the identification of regulatory kinases is important for understanding sarcomere...
5.
Wong J, Blazev R, Ng Y, Goodman C, Montgomery M, Watt K, et al.
FASEB J
. 2024 May;
38(10):e23647.
PMID: 38787599
Arginine methylation is a protein posttranslational modification important for the development of skeletal muscle mass and function. Despite this, our understanding of the regulation of arginine methylation under settings of...
6.
Charitakis N, Salim A, Piers A, Watt K, Porrello E, Elliott D, et al.
Genome Biol
. 2023 Sep;
24(1):209.
PMID: 37723583
Identifying spatially variable genes (SVGs) is a key step in the analysis of spatially resolved transcriptomics data. SVGs provide biological insights by defining transcriptomic differences within tissues, which was previously...
7.
Ter Huurne M, Parker B, Liu N, Qian E, Vivien C, Karavendzas K, et al.
Am J Hum Genet
. 2023 Aug;
110(9):1600-1605.
PMID: 37607539
Recent studies in non-human model systems have shown therapeutic potential of nucleoside-modified messenger RNA (modRNA) treatments for lysosomal storage diseases. Here, we assessed the efficacy of a modRNA treatment to...
8.
Montgomery M, Bayliss J, Nie S, De Nardo W, Keenan S, Anari M, et al.
Diabetes
. 2022 Dec;
72(6):715-727.
PMID: 36580496
Nonalcoholic fatty liver disease (NAFLD) and impaired glycemic control are closely linked; however, the pathophysiological mechanisms underpinning this bidirectional relationship remain unresolved. The high secretory capacity of the liver and...
9.
Molendijk J, Blazev R, Mills R, Ng Y, Watt K, Chau D, et al.
Elife
. 2022 Dec;
11.
PMID: 36472367
Improving muscle function has great potential to improve the quality of life. To identify novel regulators of skeletal muscle metabolism and function, we performed a proteomic analysis of gastrocnemius muscle...
10.
Sartori R, Hagg A, Zampieri S, Armani A, Winbanks C, Viana L, et al.
Sci Transl Med
. 2021 Aug;
13(605).
PMID: 34349036
Most patients with advanced solid cancers exhibit features of cachexia, a debilitating syndrome characterized by progressive loss of skeletal muscle mass and strength. Because the underlying mechanisms of this multifactorial...