Kevin I Watt
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Explore the profile of Kevin I Watt including associated specialties, affiliations and a list of published articles.
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21
Citations
775
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Recent Articles
11.
Bond S, Zhuang A, Yang C, Gould E, Sikora T, Liu Y, et al.
Mol Metab
. 2021 Jul;
53:101292.
PMID: 34246805
Objective: CRISPR/Cas9 technology has revolutionized gene editing and fast tracked our capacity to manipulate genes of interest for the benefit of both research and therapeutic applications. Whilst many advances have,...
12.
Sim C, Phipson B, Ziemann M, Rafehi H, Mills R, Watt K, et al.
Circulation
. 2021 Mar;
143(16):1614-1628.
PMID: 33682422
Background: Despite in-depth knowledge of the molecular mechanisms controlling embryonic heart development, little is known about the signals governing postnatal maturation of the human heart. Methods: Single-nucleus RNA sequencing of...
13.
Blazev R, Ashwood C, Abrahams J, Chung L, Francis D, Yang P, et al.
Mol Cell Proteomics
. 2021 Feb;
20:100030.
PMID: 33583770
Many cell surface and secreted proteins are modified by the covalent addition of glycans that play an important role in the development of multicellular organisms. These glycan modifications enable communication...
14.
Davey J, Estevez E, Thomson R, Whitham M, Watt K, Hagg A, et al.
FASEB J
. 2020 Mar;
34(4):5697-5714.
PMID: 32141144
Type 2 diabetes (T2D) manifests from inadequate glucose control due to insulin resistance, hypoinsulinemia, and deteriorating pancreatic β-cell function. The pro-inflammatory factor Activin has been implicated as a positive correlate...
15.
Findeisen M, Allen T, Henstridge D, Kammoun H, Brandon A, Baggio L, et al.
Nature
. 2019 Sep;
574(7776):63-68.
PMID: 31554967
The gp130 receptor cytokines IL-6 and CNTF improve metabolic homeostasis but have limited therapeutic use for the treatment of type 2 diabetes. Accordingly, we engineered the gp130 ligand IC7Fc, in...
16.
Watt K, Goodman C, Hornberger T, Gregorevic P
Exerc Sport Sci Rev
. 2018 Jan;
46(2):92-96.
PMID: 29346163
The Hippo signaling pathway regulates the activity of the proteins Yes-associated protein (Yap) and transcriptional co-activator with PDZ-binding motif (Taz) to control tissue growth in many different cell types. Previously,...
17.
Whitham M, Parker B, Friedrichsen M, Hingst J, Hjorth M, Hughes W, et al.
Cell Metab
. 2018 Jan;
27(1):237-251.e4.
PMID: 29320704
Exercise stimulates the release of molecules into the circulation, supporting the concept that inter-tissue signaling proteins are important mediators of adaptations to exercise. Recognizing that many circulating proteins are packaged...
18.
Watt K, Harvey K, Gregorevic P
Front Physiol
. 2017 Dec;
8:942.
PMID: 29225579
The integrative control of diverse biological processes such as proliferation, differentiation, apoptosis and metabolism is essential to maintain cellular and tissue homeostasis. Disruption of these underlie the development of many...
19.
Davey J, Watt K, Parker B, Chaudhuri R, Ryall J, Cunningham L, et al.
JCI Insight
. 2016 May;
1(5).
PMID: 27182554
The transforming growth factor-β (TGF-β) signaling network is a critical regulator of skeletal muscle mass and function and, thus, is an attractive therapeutic target for combating muscle disease, but the...
20.
Winbanks C, Chen J, Qian H, Liu Y, Bernardo B, Beyer C, et al.
J Cell Biol
. 2013 Oct;
203(2):345-57.
PMID: 24145169
Although the canonical transforming growth factor β signaling pathway represses skeletal muscle growth and promotes muscle wasting, a role in muscle for the parallel bone morphogenetic protein (BMP) signaling pathway...