Kenneth R Peterson
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Explore the profile of Kenneth R Peterson including associated specialties, affiliations and a list of published articles.
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46
Citations
1054
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Recent Articles
1.
Gabrielli A, Weidling I, Ranjan A, Wang X, Novikova L, Chowdhury S, et al.
J Alzheimers Dis
. 2023 Feb;
92(2):591-604.
PMID: 36776072
Background: Mitochondria can trigger Alzheimer's disease (AD)-associated molecular phenomena, but how mitochondria impact apolipoprotein E (APOE; apoE) is not well known. Objective: Consider whether and how mitochondrial biology influences APOE...
2.
Parker M, Peterson K, Slawson C
Cancers (Basel)
. 2021 Apr;
13(7).
PMID: 33916244
O-linked β-N-acetylglucosamine (O-GlcNAc) is a single sugar post-translational modification (PTM) of intracellular proteins linking nutrient flux through the Hexosamine Biosynthetic Pathway (HBP) to the control of cis-regulatory elements in the...
3.
Zhu X, Xi C, Ward A, Takezaki M, Shi H, Peterson K, et al.
Exp Biol Med (Maywood)
. 2020 Jul;
245(15):1308-1318.
PMID: 32715783
Sickle cell disease is an inherited hemoglobin disorder that affects over 100,000 people in the United States causing high morbidity and early mortality. Although new treatments were recently approved by...
4.
Stavrou E, Simantirakis E, Verras M, Barbas 3rd C, Vassilopoulos G, Peterson K, et al.
Sci Rep
. 2019 Dec;
9(1):19765.
PMID: 31874995
We report the development of episomal vectors for the specific γ-globin transcription activation in its native position by activator Zif-VP64, based on the Scaffold/Matrix Attachment Region (S/MAR) for episomal retention...
5.
Debrand E, Chakalova L, Miles J, Dai Y, Goyenechea B, Dye S, et al.
PLoS One
. 2019 Aug;
14(8):e0217532.
PMID: 31412036
Transcriptome analyses show a surprisingly large proportion of the mammalian genome is transcribed; much more than can be accounted for by genes and introns alone. Most of this transcription is...
6.
Oseghale A, Zhu X, Li B, Peterson K, Nudelman A, Rephaeli A, et al.
Blood Cells Mol Dis
. 2019 Jul;
79:102345.
PMID: 31351219
Pharmacologic induction of fetal hemoglobin (HbF) is an effective strategy for treating sickle cell disease (SCD) by ameliorating disease severity. Hydroxyurea is the only FDA-approved agent that induces HbF, but...
7.
Tang Q, Villar M, Artigues A, Thyfault J, Apte U, Zhu H, et al.
Sci Rep
. 2019 Jun;
9(1):9031.
PMID: 31227746
Development of drugs that allosterically regulate enzyme functions to treat disease is a costly venture. Amino acid susbstitutions that mimic allosteric effectors in vitro will identify therapeutic regulatory targets enhancing...
8.
Zhang Z, Parker M, Graw S, Novikova L, Fedosyuk H, Fontes J, et al.
J Biol Chem
. 2018 Dec;
294(4):1363-1379.
PMID: 30523150
The addition of a single β-d-GlcNAc sugar (-GlcNAc) by -GlcNAc-transferase (OGT) and -GlcNAc removal by -GlcNAcase (OGA) maintain homeostatic -GlcNAc levels on cellular proteins. Changes in protein -GlcNAcylation regulate cellular...
9.
Parnell S, Magenheimer B, Maser R, Pavlov T, Havens M, Hastings M, et al.
Hum Mol Genet
. 2018 Jun;
27(19):3313-3324.
PMID: 29931260
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the growth of renal cysts that ultimately destroy kidney function. Mutations in the PKD1 and PKD2 genes cause ADPKD. Their protein...
10.
Parker M, Peterson K
Methods Mol Biol
. 2017 Oct;
1698:37-65.
PMID: 29076083
Animal models of erythropoiesis have been, and will continue to be, important tools for understanding molecular mechanisms underlying the development of this cell lineage and the pathophysiology associated with various...