Mouse Models of Erythropoiesis and Associated Diseases

Overview

Journal Methods Mol Biol

Specialty Molecular Biology

Date 2017 Oct 28

PMID 29076083

Citations 6

Authors

Matthew P Parker

Kenneth R Peterson

Affiliations

Soon will be listed here.

Abstract

Animal models of erythropoiesis have been, and will continue to be, important tools for understanding molecular mechanisms underlying the development of this cell lineage and the pathophysiology associated with various human erythropoietic diseases. In this regard, the mouse is probably the most valuable animal model available to investigators. The physiology and short gestational period of mice make them ideal for studying developmental processes and modeling human diseases. These attributes, coupled with cutting-edge genetic tools such as transgenesis, gene knockouts, conditional gene knockouts, and genome editing, provide a significant resource to the research community to test a plethora of hypotheses. This review summarizes the mouse models available for studying a wide variety of erythroid-related questions, as well as the properties inherent in each one.

Citing Articles

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